M
Mizuho Nakayama
Researcher at Kanazawa University
Publications - 25
Citations - 667
Mizuho Nakayama is an academic researcher from Kanazawa University. The author has contributed to research in topics: Colorectal cancer & Medicine. The author has an hindex of 9, co-authored 17 publications receiving 352 citations. Previous affiliations of Mizuho Nakayama include Japan Agency for Medical Research and Development.
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Journal ArticleDOI
Mutant p53 in colon cancer.
Mizuho Nakayama,Masanobu Oshima +1 more
TL;DR: Results indicate that missense-type p53 mutations together with loss of wild- type p53 accelerate the late stage of colorectal cancer progression through the activation of both oncogenic and inflammatory pathways.
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Combined mutation of Apc, Kras, and Tgfbr2 effectively drives metastasis of intestinal cancer
Eri Sakai,Eri Sakai,Mizuho Nakayama,Mizuho Nakayama,Hiroko Oshima,Hiroko Oshima,Yuta Kouyama,Atsushi Niida,Satoshi Fujii,Atsushi Ochiai,Keiichi I. Nakayama,Koshi Mimori,Yutaka Suzuki,Chang Pyo Hong,Chan Young Ock,Seong-Jin Kim,Masanobu Oshima,Masanobu Oshima +17 more
TL;DR: Results show how activation of Wnt and Kras with suppression of TGFβ signaling in intestinal epithelial cells is sufficient for colorectal cancer metastasis, with possible implications for the development of metastasis prevention strategies.
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CRISPR-Cas9–mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes
Haruna Takeda,Shiho Kataoka,Mizuho Nakayama,Mohamed A.E. Ali,Hiroko Oshima,Daisuke Yamamoto,Jun Won Park,Yujiro Takegami,Tadaichi An,Nancy A. Jenkins,Neal G. Copeland,Masanobu Oshima +11 more
TL;DR: In this article, a platform for functional validation of CRC driver genes using CRISPR-Cas9 in mouse intestinal tumor organoids and human CRC-derived organoids in xenograft mouse models is described.
Journal ArticleDOI
Suppressing TGFβ Signaling in Regenerating Epithelia in an Inflammatory Microenvironment Is Sufficient to Cause Invasive Intestinal Cancer
Hiroko Oshima,Mizuho Nakayama,Tae Su Han,Kuniko Naoi,Xiaoli Ju,Yusuke Maeda,Sylvie Robine,Kiichiro Tsuchiya,Toshiro Sato,Hiroshi Sato,Makoto Mark Taketo,Masanobu Oshima +11 more
TL;DR: It is indicated that a simple genetic alteration in the TGFβ signaling pathway in the inflamed and regenerating intestinal mucosa can cause invasive intestinal tumors and such a mechanism may play a role in the colon carcinogenesis associated with inflammatory bowel disease in humans.
Journal ArticleDOI
Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation.
Mizuho Nakayama,Eri Sakai,Kanae Echizen,Kanae Echizen,Yoichi Yamada,Hiroko Oshima,Tae-Su Han,Tae-Su Han,Rieko Ohki,S. Fujii,Atsushi Ochiai,Sylvie Robine,Dominic Chih-Cheng Voon,Tomoaki Tanaka,Tomoaki Tanaka,M. M. Taketo,M. M. Taketo,Masanobu Oshima,Masanobu Oshima +18 more
TL;DR: The results indicate that nuclear-accumulated mutant p53R270H induces malignant progression of intestinal tumors through complex tumor gland formation and acquisition of invasiveness, and is a potential therapeutic target for the treatment of advanced CRCs.