Journal ArticleDOI
Pyruvate kinase M2 and cancer: An updated assessment
TLDR
Constant evidence suggests a critical role played by the low‐activity‐dimeric PKM2 in tumor progression, supported by the identification of mutations which result in the down‐regulation of its activity and tumorigenesis in a nude mouse model.About:
This article is published in FEBS Letters.The article was published on 2014-08-19. It has received 164 citations till now. The article focuses on the topics: PKM2 & Pyruvate kinase.read more
Citations
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Revisiting the hallmarks of cancer.
Yousef A. Fouad,Carmen Aanei +1 more
TL;DR: This work defines seven hallmarks of cancer: selective growth and proliferative advantage, altered stress response favoring overall survival, vascularization, invasion and metastasis, metabolic rewiring, an abetting microenvironment, and immune modulation, while highlighting some considerations for the future of the field.
Journal ArticleDOI
Revisiting the Warburg effect: historical dogma versus current understanding.
TL;DR: The Warburg effect as discussed by the authors is an essential part of a'selfish' metabolic reprogramming, which results from the interplay between (normoxic/hypoxic) hypoxia-inducible factor-1 (HIF-1) overexpression, oncogene activation (cMyc, Ras), loss of function of tumour suppressors (mutant p53, mutant phosphatase and tensin homologue (PTEN), microRNAs and sirtuins with suppressor functions), activated (PI3K-Akt-mTOR
Journal ArticleDOI
PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation.
Ninel Azoitei,Alexander Becher,Konrad Steinestel,Arefeh Rouhi,Kristina Diepold,Felicitas Genze,Thomas Simmet,Thomas Seufferlein +7 more
TL;DR: This study suggests that in hypoxic pancreatic tumors PKM2 interferes both with NF-κB/p65 and HIF-1α activation that ultimately triggers VEGF-A secretion and subsequent blood vessel formation.
Journal ArticleDOI
PKM2, function and expression and regulation
TL;DR: This paper will use the switching effect of PKM2 in glucose metabolism as the entry point to expand and enrich the Warburg effect, and illustrate the different intracellular localization ofPKM2 and then exert specific biological functions.
Journal ArticleDOI
How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions
Hubert Lincet,Philippe Icard +1 more
TL;DR: The multiple non-glycolytic roles of gly colytic enzymes, which are essential for promoting cancer cells' survival, proliferation, chemoresistance and dissemination, are outlined.
References
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Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Book
Principles of Biochemistry
TL;DR: The third edition, coming ten years after the first, emphasizes both the flowering of biochemical research and the prodigious effort by busy teachers and scientists to keep up to date this popular text and reference.
Journal ArticleDOI
Why do cancers have high aerobic glycolysis
TL;DR: In this article, the authors propose that persistent metabolism of glucose to lactate even in aerobic conditions is an adaptation to intermittent hypoxia in pre-malignant lesions, which leads to microenvironmental acidosis requiring evolution to phenotypes resistant to acid-induced cell toxicity.
Related Papers (5)
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Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
Taro Hitosugi,Sumin Kang,Matthew G. Vander Heiden,Tae-Wook Chung,Shannon Elf,Katherine Lythgoe,Shaozhong Dong,Sagar Lonial,Xu Wang,Georgia Z. Chen,Jianxin Xie,Ting-Lei Gu,Roberto D. Polakiewicz,Johannes Roesel,Titus J. Boggon,Fadlo R. Khuri,D. Gary Gilliland,Lewis C. Cantley,Jonathan L. Kaufman,Jing Chen +19 more