Mojun Shen

TL;DR: In this article, the authors examined whether a genomic profile risk score for major depressive disorder (GPRSMDD) moderates the association between antenatal maternal depressive symptoms (or socioeconomic status, SES) and fetal neurodevelopment, and identified candidate biological processes underlying such association.

TL;DR: The study revealed that genetic variants in neonatal FKBP5 moderate the association between antenatal maternal depressive symptoms and right hippocampal volume but only show a trend for such moderation on amygdala volumes and cortical thickness.

TL;DR: In this article, the authors investigated the genomic signatures in the ventral hippocampus common to mouse models of stress using RNA-sequencing and found that differentially expressed genes (DEGs) were concordant for gene networks involved in neurotransmission, cytoskeleton function, and vascularization.

TL;DR: Interestingly, the genes in PRScross, that contributed most to aging neurodegeneration, were expressed in the functioanlly connected cortical regions.

TL;DR: In this paper , the authors defined an expression signature of homeostatic inflammation in the term placenta and used expression quantitative trait loci (eQTLs) to create a polygenic score (PGS) predictive of its expression.