Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk.
Anqi Qiu,Mojun Shen,Claudia Buss,Claudia Buss,Yap Seng Chong,Kenneth Kwek,Seang-Mei Saw,Peter D. Gluckman,Pathik D. Wadhwa,Sonja Entringer,Sonja Entringer,Martin Styner,Neerja Karnani,Christine Heim,Christine Heim,Kieran J. O’Donnell,Kieran J. O’Donnell,Joanna D. Holbrook,Marielle V. Fortier,Michael J. Meaney,Michael J. Meaney +20 more
TLDR
In this article, the authors examined whether a genomic profile risk score for major depressive disorder (GPRSMDD) moderates the association between antenatal maternal depressive symptoms (or socioeconomic status, SES) and fetal neurodevelopment, and identified candidate biological processes underlying such association.Abstract:
This study included 168 and 85 mother-infant dyads from Asian and United States of America cohorts to examine whether a genomic profile risk score for major depressive disorder (GPRSMDD) moderates the association between antenatal maternal depressive symptoms (or socio-economic status, SES) and fetal neurodevelopment, and to identify candidate biological processes underlying such association. Both cohorts showed a significant interaction between antenatal maternal depressive symptoms and infant GPRSMDD on the right amygdala volume. The Asian cohort also showed such interaction on the right hippocampal volume and shape, thickness of the orbitofrontal and ventromedial prefrontal cortex. Likewise, a significant interaction between SES and infant GPRSMDD was on the right amygdala and hippocampal volumes and shapes. After controlling for each other, the interaction effect of antenatal maternal depressive symptoms and GPRSMDD was mainly shown on the right amygdala, while the interaction effect of SES and GPRSMDD was mainly shown on the right hippocampus. Bioinformatic analyses suggested neurotransmitter/neurotrophic signaling, SNAp REceptor complex, and glutamate receptor activity as common biological processes underlying the influence of antenatal maternal depressive symptoms on fetal cortico-limbic development. These findings suggest gene-environment interdependence in the fetal development of brain regions implicated in cognitive-emotional function. Candidate biological mechanisms involve a range of brain region-specific signaling pathways that converge on common processes of synaptic development.read more
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Treatment resistant depression: A multi-scale, systems biology approach.
Huda Akil,Joshua A. Gordon,René Hen,Jonathan A. Javitch,Helen S. Mayberg,Bruce S. McEwen,Michael J. Meaney,Eric J. Nestler +7 more
TL;DR: A multi‐scale framework for fundamental research on depression is proposed, aimed at identifying the brain circuits that are dysfunctional in several animal models of depression as well the changes in gene expression that are associated with these models.
Journal ArticleDOI
Prenatal maternal stress, fetal programming, and mechanisms underlying later psychopathology-A global perspective
TL;DR: It is now time to understand more about prenatal stress and psychopathology, and the role of both social and biological differences, in the rest of the world.
Journal ArticleDOI
Early environmental influences on the development of children's brain structure and function.
Patrícia Maidana Miguel,Lenir Orlandi Pereira,Patrícia Pelufo Silveira,Patrícia Pelufo Silveira,Michael J. Meaney +4 more
TL;DR: Evidence linking adverse environmental variation during early life and long‐term changes in brain volume, microstructure, and connectivity and genetic variations that moderate the impact of adverse environmental conditions on child neurodevelopment are described.
Journal ArticleDOI
Paediatric population neuroimaging and the Generation R Study: the second wave
Tonya White,Ryan L. Muetzel,Hanan El Marroun,Laura M. E. Blanken,Philip R. Jansen,Koen Bolhuis,Desana Kocevska,Sabine E. Mous,Rosa H. Mulder,Vincent W. V. Jaddoe,Aad van der Lugt,Frank C. Verhulst,Frank C. Verhulst,Henning Tiemeier +13 more
TL;DR: An overview of the imaging protocol and the overlap between the neuroimaging data and metadata is provided, which highlights a diverse array of questions that can be addressed by merging the fields of developmental neuroscience and epidemiology.
Journal ArticleDOI
Translating basic research knowledge on the biological embedding of early-life stress into novel approaches for the developmental programming of lifelong health.
TL;DR: This review integrates scientific knowledge obtained over the past few decades on the biological mechanisms that contribute to the profound association between exposure to early adversity, including childhood trauma and prenatal stress, and the lifelong elevated risk to develop a broad range of diseases.
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TL;DR: The extent to which common genetic variation underlies the risk of schizophrenia is shown, using two analytic approaches, and the major histocompatibility complex is implicate, which is shown to involve thousands of common alleles of very small effect.