J
Joanna D. Holbrook
Researcher at University of Southampton
Publications - 77
Citations - 4900
Joanna D. Holbrook is an academic researcher from University of Southampton. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 33, co-authored 77 publications receiving 4121 citations. Previous affiliations of Joanna D. Holbrook include GlaxoSmithKline & Southampton General Hospital.
Papers
More filters
Journal ArticleDOI
Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators.
Lisa Patel,Amy C Buckels,Ian J. Kinghorn,Paul R. Murdock,Joanna D. Holbrook,C Plumpton,Colin H. Macphee,Stephen A. Smith +7 more
TL;DR: The data support a direct role for PPAR gamma in the regulation of resistin expression and identify several putative PPAR response elements of which one was shown to bind PPAR Gamma using electrophoretic mobility shift assays.
Journal ArticleDOI
Cohort Profile: Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study
Shu E Soh,Mya Thway Tint,Peter D. Gluckman,Keith M. Godfrey,Anne Rifkin-Graboi,Yiong-Huak Chan,Walter Stünkel,Joanna D. Holbrook,Kenneth Kwek,Yap Seng Chong,Seang-Mei Saw +10 more
TL;DR: This paper aims to provide a history of infectious disease in Singapore over a 50-year period and some of the main causes and treatments were identified in the period up to and including the year in question.
Journal ArticleDOI
The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes
Ai Ling Teh,Hong Pan,Li Chen,Mei-Lyn Ong,Shaillay Kumar Dogra,Johnny Wong,Julia L. MacIsaac,Sarah M Mah,Lisa M. McEwen,Seang-Mei Saw,Keith M. Godfrey,Yap Seng Chong,Kenneth Kwek,Chee Keong Kwoh,Shu E Soh,Mary Ff F. Chong,Mary Ff F. Chong,Sheila J. Barton,Neerja Karnani,Clara Y. Cheong,Jan Paul Buschdorf,Walter Stünkel,Michael S. Kobor,Michael J. Meaney,Peter D. Gluckman,Joanna D. Holbrook +25 more
TL;DR: This study surveyed the genotypes and DNA methylomes of 237 neonates and found 1423 punctuate regions of the methylome that were highly variable across individuals, termed variably methylated regions (VMRs), against a backdrop of homogeneity.
Journal ArticleDOI
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
Norihiro Kato,Marie Loh,Marie Loh,Marie Loh,Fumihiko Takeuchi,Niek Verweij,Xu Wang,Weihua Zhang,Tanika NKelly,Danish Saleheen,Danish Saleheen,Benjamin Lehne,Irene Mateo Leach,Alexander W. Drong,James Abbott,Simone Wahl,Sian Tsung Tan,William R. Scott,Gianluca Campanella,Marc Chadeau-Hyam,Uzma Afzal,Tarunveer S. Ahluwalia,Tarunveer S. Ahluwalia,Marc Jan Bonder,Peng Chen,Abbas Dehghan,Todd L. Edwards,Tõnu Esko,Min Jin Go,Sarah E. Harris,Jaana Hartiala,Silva Kasela,Anuradhani Kasturiratne,Chiea Chuen Khor,Marcus E. Kleber,Huaixing Li,Zuan Yu Mok,Masahiro Nakatochi,Nur Sabrina Sapari,Richa Saxena,Alexandre F.R. Stewart,Lisette Stolk,Yasuharu Tabara,Ai Ling Teh,Ying Wu,Jer-Yuarn Wu,Yi Zhang,Imke Aits,Alexessander Couto Alves,Shikta Das,Rajkumar Dorajoo,Jemma CHopewell,Yun Kyoung Kim,Robert WKoivula,Jian'an Luan,Leo-Pekka Lyytikäinen,Quang NNguyen,Mark A. Pereira,Iris Postmus,Olli TRaitakari,Molly Scannell Bryan,Robert A. Scott,Rossella Sorice,Vinicius Tragante,Michela Traglia,Jon White,Ken Yamamoto,Yonghong Zhang,Linda S. Adair,Alauddin Ahmed,Koichi Akiyama,Rasheed Asif,Tin Aung,Inês Barroso,Andrew Bjonnes,Timothy R. Braun,Hui Cai,Li Ching Chang,Chien Hsiun Chen,Ching-Yu Cheng,Yap Seng Chong,Yap Seng Chong,Rory Collins,Regina Courtney,Gail Davies,Graciela E. Delgado,Loi D. Do,Pieter A. Doevendans,Ron T. Gansevoort,Yu-Tang Gao,Tanja B. Grammer,Niels Grarup,Jagvir Grewal,Dongfeng Gu,Gurpreet SWander,Anna-Liisa Hartikainen,Stanley L. Hazen,Jing He,Chew-Kiat Heng,E. James Ames Hixso,Albert Hofman,Chris Hsu,Wei Huang,Lise Lotte N. Husemoen,Joo Yeon Hwang,Sahoko Ichihara,Michiya Igase,Masato Isono,Johanne Marie Justesen,Tomohiro Katsuya,Muhammad GKibriya,Young Jin Kim,Miyako Kishimoto,Woon-Puay Koh,Katsuhiko Kohara,Meena Kumari,Kenneth Kwek,Nanette R. Lee,Jeannette Lee,Jiemin Liao,Jiemin Liao,Wolfgang Lieb,David C. Liewald,Tatsuaki Matsubara,Yumi Matsushita,Thomas Meitinger,Evelin Mihailov,Lili Milani,Rebecca Mills,Nina Mononen,Martina Müller-Nurasyid,Toru Nabika,Eitaro Nakashima,Hong Kiat Ng,Kjell Nikus,Teresa Nutile,Takayoshi Ohkubo,Keizo Ohnaka,Sarah Parish,Lavinia Paternoster,Hao Peng,Annette Peters,Son TPham,M.J. Pinidiyapathirage,Mahfuzar Rahman,Hiromi Rakugi,Olov Rolandsson,Michelle Ann Rozario,Daniela Ruggiero,Cinzia Sala,Ralhan Sarju,Kazuro Shimokawa,Harold Snieder,Thomas Sparsø,Wilko Spiering,John M. Starr,David J. Stott,Daniel OStram,Takao Sugiyama,Silke Szymczak,W.H. Wilson Tang,Lin Tong,Stella Trompet,Väinö Turjanmaa,Hirotsugu Ueshima,André G. Uitterlinden,Satoshi Umemura,Marja Vääräsmäki,Rob M. van Dam,Wiek H. van Gilst,Dirk J. van Veldhuisen,Jorma Viikari,Melanie Waldenberger,Yiqin Wang,Aili Wang,Rory P. Wilson,Tien Yin Wong,Tien Yin Wong,Yong-Bing Xiang,Shuhei Yamaguchi,Xingwang Ye,Robin Young,Terri L. Young,Jian-Min Yuan,Xueya Zhou,Folkert W. Asselbergs,Folkert W. Asselbergs,Marina Ciullo,Robert Clarke,Panos Deloukas,Panos Deloukas,Andre Franke,W. Frank Paul,Steve Franks,Yechiel Friedlander,Myron D. Gross,Zhirong Guo,Torben Hansen,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Torben Jørgensen,J. Wouter Jukema,Mika Kähönen,Hiroshi Kajio,Mika Kivimäki,Jong-Young Lee,Terho Lehtimäki,Allan Linneberg,Tetsuro Miki,Oluf Pedersen,Nilesh J. Samani,Thorkild I. A. Sørensen,Thorkild I. A. Sørensen,Ryoichi Takayanagi,Daniela Toniolo,Habibul Ahsan,Hooman Allayee,Yuan-Tsong Chen,John Danesh,John Danesh,Ian J. Deary,Oscar H. Franco,Lude Franke,Bastiaan THeijman,Joanna D. Holbrook,Aaron Isaacs,Bong Jo Kim,Xu Lin,Jianjun Liu,Winfried März,Andres Metspalu,Karen L. Mohlke,K. Sangher,Dharambir Harambir,Xiao-Ou Shu,Joyce B. J. van Meurs,Eranga N. Vithana,Ananda R. Wickremasinghe,Cisca Wijmenga,Bruce H W Wolffenbuttel,Mitsuhiro Yokota,Wei Zheng,Dingliang Zhu,Paolo Vineis,Soterios A. Kyrtopoulos,Jos C. S. Kleinjans,Mark I. McCarthy,Richie Soong,Christian Gieger,James Scott,Yik Ying Teo,Jiang He,Paul Elliott,E. Shyong Tai,Pim van der Harst,Jaspal S. Kooner,John C. Chambers +256 more
TL;DR: The trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry finds genetic variants at 12 new loci to be associated with blood pressure, providing new evidence for the role of DNA methylation in blood pressure regulation.
Journal ArticleDOI
Dynamics of Infant Gut Microbiota Are Influenced by Delivery Mode and Gestational Duration and Are Associated with Subsequent Adiposity
Shaillay Kumar Dogra,Olga Sakwinska,Shu E Soh,Catherine Ngom-Bru,Wolfram M. Brück,Bernard Berger,Harald Brüssow,Yung Seng Lee,Fabian Yap,Yap Seng Chong,Keith M. Godfrey,Joanna D. Holbrook +11 more
TL;DR: Independently of the delivery mode and gestation duration, infants who acquired a profile high in Bifidobacterium and Collinsella at a later age had lower adiposity at 18 months of age.