M
Mojun Shen
Researcher at Agency for Science, Technology and Research
Publications - 5
Citations - 145
Mojun Shen is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 2, co-authored 4 publications receiving 91 citations.
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Journal ArticleDOI
Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk.
Anqi Qiu,Mojun Shen,Claudia Buss,Claudia Buss,Yap Seng Chong,Kenneth Kwek,Seang-Mei Saw,Peter D. Gluckman,Pathik D. Wadhwa,Sonja Entringer,Sonja Entringer,Martin Styner,Neerja Karnani,Christine Heim,Christine Heim,Kieran J. O’Donnell,Kieran J. O’Donnell,Joanna D. Holbrook,Marielle V. Fortier,Michael J. Meaney,Michael J. Meaney +20 more
TL;DR: In this article, the authors examined whether a genomic profile risk score for major depressive disorder (GPRSMDD) moderates the association between antenatal maternal depressive symptoms (or socioeconomic status, SES) and fetal neurodevelopment, and identified candidate biological processes underlying such association.
Journal ArticleDOI
FKBP5 Moderates the Association between Antenatal Maternal Depressive Symptoms and Neonatal Brain Morphology.
Changqing Wang,Mojun Shen,Bryan Guillaume,Yap Seng Chong,Helen Chen,Marielle V. Fortier,Michael J. Meaney,Michael J. Meaney,Anqi Qiu +8 more
TL;DR: The study revealed that genetic variants in neonatal FKBP5 moderate the association between antenatal maternal depressive symptoms and right hippocampal volume but only show a trend for such moderation on amygdala volumes and cortical thickness.
Journal ArticleDOI
Genomic modules and intramodular network concordance in susceptible and resilient male mice across models of stress.
Salvatore G. Caradonna,Tie-Yuan Zhang,Nicholas O’Toole,Mojun Shen,Huzefa Khalil,Nathan R. Einhorn,Xianglan Wen,Carine Parent,Francis S. Lee,Huda Akil,Michael J. Meaney,Bruce S. McEwen,Jordan Marrocco +12 more
TL;DR: In this article, the authors investigated the genomic signatures in the ventral hippocampus common to mouse models of stress using RNA-sequencing and found that differentially expressed genes (DEGs) were concordant for gene networks involved in neurotransmission, cytoskeleton function, and vascularization.
Journal ArticleDOI
Psychiatric polygenic risk associates with cortical morphology and functional organization in aging.
TL;DR: Interestingly, the genes in PRScross, that contributed most to aging neurodegeneration, were expressed in the functioanlly connected cortical regions.
Posted ContentDOI
Homeostatic inflammation in the placenta is protective against adult cardiovascular and depressive outcomes
Eamon Fitzgerald,Mojun Shen,Hannah Ee Juen Yong,Z. P. Wang,Irina Pokhvisneva,S. Patel,Nick O’Toole,Shiao-Yng Chan,H. Chen,Peter D. Gluckman,J. K. Chan,Pao-Lin Lee,Micheal Meaney +12 more
TL;DR: In this paper , the authors defined an expression signature of homeostatic inflammation in the term placenta and used expression quantitative trait loci (eQTLs) to create a polygenic score (PGS) predictive of its expression.