M
Monique I. J. Spronken
Researcher at Erasmus University Rotterdam
Publications - 40
Citations - 2299
Monique I. J. Spronken is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 19, co-authored 35 publications receiving 1912 citations. Previous affiliations of Monique I. J. Spronken include Solvay.
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Journal ArticleDOI
Substitutions near the receptor binding site determine major antigenic change during influenza virus evolution.
Björn F. Koel,David F. Burke,Theo M. Bestebroer,Stefan van der Vliet,Gerben C. M. Zondag,Gaby Vervaet,Eugene Skepner,Nicola S. Lewis,Monique I. J. Spronken,Colin A. Russell,Mikhail Y. Eropkin,Aeron C. Hurt,Ian G. Barr,Jan C. de Jong,Guus F. Rimmelzwaan,Albert D. M. E. Osterhaus,Ron A. M. Fouchier,Derek J. Smith +17 more
TL;DR: The findings of Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions, which substantially skew the way the immune system “sees” the virus.
Journal ArticleDOI
Transmission routes of respiratory viruses among humans.
TL;DR: An overview of the available data from experimental and observational studies on the transmission routes of respiratory viruses between humans is presented, knowledge gaps are identified, and how the available knowledge is currently implemented in isolation guidelines in health care settings is discussed.
Journal ArticleDOI
Efficient generation and growth of influenza virus A/PR/8/34 from eight cDNA fragments.
Emmie de Wit,Monique I. J. Spronken,Theo M. Bestebroer,Guus F. Rimmelzwaan,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +5 more
TL;DR: High-titer virus stocks of recombinant influenza A/PR/8/34 virus can be produced as well as virus stocks with much lower titers, but without the requirement of virus amplification through replication.
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Limited airborne transmission of H7N9 influenza A virus between ferrets
Mathilde Richard,Eefje J. A. Schrauwen,Miranda de Graaf,Theo M. Bestebroer,Monique I. J. Spronken,Sander van Boheemen,Dennis de Meulder,Pascal Lexmond,Martin Linster,Sander Herfst,Derek J. Smith,Judith M. A. van den Brand,David F. Burke,Thijs Kuiken,Guus F. Rimmelzwaan,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +16 more
TL;DR: It is shown that although the A/Anhui/1/2013 A(H7N9) virus harbours determinants associated with human adaptation and transmissibility between mammals, its airborneTransmissibility in ferrets is limited, and it is intermediate between that of typical human and avian influenza viruses.
Journal ArticleDOI
Adenosine Deaminase Acts as a Natural Antagonist for Dipeptidyl Peptidase 4-Mediated Entry of the Middle East Respiratory Syndrome Coronavirus
V. Stalin Raj,Saskia L. Smits,Lisette B. Provacia,Judith M. A. van den Brand,Lidewij Wiersma,Werner J. D. Ouwendijk,Theo M. Bestebroer,Monique I. J. Spronken,Geert van Amerongen,Peter J. M. Rottier,Ron A. M. Fouchier,Berend Jan Bosch,Albert D. M. E. Osterhaus,Bart L. Haagmans +13 more
TL;DR: Resistance of ferrets to MERS-CoV infection and inability of ferret DDP4 to bind MSPV are shown, and site-directed mutagenesis of amino acids variable in ferrets DPP4 revealed the functional human D PP4 virus binding site.