Journal ArticleDOI
Substitutions near the receptor binding site determine major antigenic change during influenza virus evolution.
Björn F. Koel,David F. Burke,Theo M. Bestebroer,Stefan van der Vliet,Gerben C. M. Zondag,Gaby Vervaet,Eugene Skepner,Nicola S. Lewis,Monique I. J. Spronken,Colin A. Russell,Mikhail Y. Eropkin,Aeron C. Hurt,Ian G. Barr,Jan C. de Jong,Guus F. Rimmelzwaan,Albert D. M. E. Osterhaus,Ron A. M. Fouchier,Derek J. Smith +17 more
TLDR
The findings of Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions, which substantially skew the way the immune system “sees” the virus.Abstract:
The molecular basis of antigenic drift was determined for the hemagglutinin (HA) of human influenza A/H3N2 virus. From 1968 to 2003, antigenic change was caused mainly by single amino acid substitutions, which occurred at only seven positions in HA immediately adjacent to the receptor binding site. Most of these substitutions were involved in antigenic change more than once. Equivalent positions were responsible for the recent antigenic changes of influenza B and A/H1N1 viruses. Substitution of a single amino acid at one of these positions substantially changed the virus-specific antibody response in infected ferrets. These findings have potentially far-reaching consequences for understanding the evolutionary mechanisms that govern influenza viruses.read more
Citations
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Journal ArticleDOI
Modeling infectious disease dynamics in the complex landscape of global health.
Hans Heesterbeek,Roy M. Anderson,Viggo Andreasen,Shweta Bansal,Daniela De Angelis,Christopher Dye,Ken T. D. Eames,W. John Edmunds,Simon D. W. Frost,Sebastian Funk,T. Déirdre Hollingsworth,T. Déirdre Hollingsworth,Thomas House,Valerie Isham,Petra Klepac,Justin Lessler,James O. Lloyd-Smith,C. Jessica E. Metcalf,Denis Mollison,Lorenzo Pellis,Juliet R. C. Pulliam,Juliet R. C. Pulliam,Mick G. Roberts,Cécile Viboud +23 more
TL;DR: The development of mathematical models used in epidemiology are reviewed and how these can be harnessed to develop successful control strategies and inform public health policy, using the West African Ebola epidemic as an example.
Journal ArticleDOI
The evolution of seasonal influenza viruses
TL;DR: Recent advances in understanding the molecular determinants of influenza virus immune escape, sources of evolutionary selection pressure, population dynamics of influenza viruses and prospects for better influenza virus control are discussed.
Journal ArticleDOI
Global circulation patterns of seasonal influenza viruses vary with antigenic drift.
Trevor Bedford,Steven Riley,Ian G. Barr,Shobha Broor,Mandeep S. Chadha,Nancy J. Cox,Rodney S. Daniels,C. Palani Gunasekaran,Aeron C. Hurt,Anne Kelso,Alexander Klimov,Nicola S. Lewis,Xiyan Li,John W. McCauley,Takato Odagiri,Varsha Potdar,Andrew Rambaut,Yuelong Shu,Eugene Skepner,Derek J. Smith,Marc A. Suchard,Masato Tashiro,Dayan Wang,Xiyan Xu,Philippe Lemey,Colin A. Russell +25 more
TL;DR: Detailed epidemic models support differences in age of infection, combined with the less frequent travel of children, as probable drivers of the differences in the patterns of global circulation, suggesting a complex interaction between virus evolution, epidemiology, and human behaviour.
Journal ArticleDOI
Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains.
Seth J. Zost,Kaela Parkhouse,Megan E. Gumina,Kangchon Kim,Sebastian Diaz Perez,Patrick C. Wilson,John J. Treanor,Andrea J. Sant,Sarah Cobey,Scott E. Hensley +9 more
TL;DR: The data suggest that influenza virus antigens prepared via systems not reliant on egg adaptations are more likely to elicit protective antibody responses that are not affected by glycosylation of antigenic site B of H3N2 HA.
Journal ArticleDOI
Low 2012–13 Influenza Vaccine Effectiveness Associated with Mutation in the Egg-Adapted H3N2 Vaccine Strain Not Antigenic Drift in Circulating Viruses
Danuta M. Skowronski,Naveed Z. Janjua,Gaston De Serres,Suzana Sabaiduc,Alireza Eshaghi,James A. Dickinson,Kevin Fonseca,Anne-Luise Winter,Jonathan B. Gubbay,Mel Krajden,Martin Petric,Hugues Charest,Nathalie Bastien,Trijntje L. Kwindt,Salaheddin M. Mahmud,Paul Van Caeseele,Yan Li +16 more
TL;DR: Detailed genotypic and phenotypic characterization shows that low VE was instead related to mutations in the egg-adapted H3N2 vaccine strain rather than antigenic drift in circulating viruses, underscore the need to monitor vaccine viruses as well as circulating strains to explain vaccine performance.
References
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Journal ArticleDOI
Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin
John J. Skehel,Don C. Wiley +1 more
TL;DR: Comparisons to the soluble N-ethyl-maleimide-sensitive factor attachment protein receptor (SNARE) protein complex of vesicle fusion suggests that these molecules are all in the fusion-activated conformation and that the juxtaposition of the membrane anchor and fusion peptide, a recurring feature, is involved in the fused mechanism.
Journal ArticleDOI
Mapping the Antigenic and Genetic Evolution of Influenza Virus
Derek J. Smith,Derek J. Smith,Alan Lapedes,Jan C. de Jong,Theo M. Bestebroer,Guus F. Rimmelzwaan,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +7 more
TL;DR: The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003 and offers a route to predicting the relative success of emerging strains.
Journal ArticleDOI
Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation
TL;DR: Four ‘antigenic sites’ on the three-dimensional structure of the influenza haemagglutinin are identified and at least one amino acid substitution in each site seems to be required for the production of new epidemic strains between 1968 and 1975.
Journal ArticleDOI
A DNA transfection system for generation of influenza A virus from eight plasmids
TL;DR: An eight-plasmid DNA transfection system for the rescue of infectious influenza A virus from cloned cDNA facilitates the design and recovery of both recombinant and reassortant influenza A viruses, and may also be applicable to the recovery of other RNA viruses entirely from cloning cDNA.
Journal ArticleDOI
Structural and Functional Bases for Broad-Spectrum Neutralization of Avian and Human Influenza A Viruses
Jianhua Sui,William C. Hwang,Sandra Elizabeth Pérez,Ge Wei,Daniel Aird,Li-Mei Chen,Eugenio Santelli,Boguslaw Stec,Greg Cadwell,Maryam Ali,Hongquan Wan,Akikazu Murakami,Anuradha Yammanuru,Thomas Han,Nancy J. Cox,Laurie A. Bankston,Ruben O. Donis,Robert C. Liddington,Wayne A. Marasco +18 more
TL;DR: The crystal structure of one such nAb bound to H5 shows that it blocks infection by inserting its heavy chain into a conserved pocket in the stem region, thus preventing membrane fusion, and suggests that nAb-based immunotherapy is a promising strategy for broad-spectrum protection against seasonal and pandemic influenza viruses.