Muhammad H. Ahsan

TL;DR: It is shown that aerosol immunization of macaques with the Mtb mutant in SigH (MtbΔsigH) results in significant recruitment of inducible bronchus-associated lymphoid tissue (iBALT) as well as CD4+ and CD8+ T cells expressing activation and proliferation markers to the lungs.

TL;DR: The DosR regulon modulates both the magnitude and the timing of adaptive immune responses in response to hypoxia in vivo, resulting in persistent infection and interference with the development of effective antituberculosis vaccines.

TL;DR: It is suggested that proteasome inhibition, perhaps through the NF-κB signaling pathway, may regulate SAA1 expression and both local and systemic induction of A-SAA occur during inflammation and may contribute to the pathogenesis of chronic inflammatory diseases associated with amyloid deposition.

TL;DR: The data are consistent with the notion that NF-κB, but not the MAPK signaling pathways, is involved in the in vivo regulation of GADD45β expression, which supports the proposed role of Gadd45β in protecting cells against DNA damaged under various stress conditions.

TL;DR: The expression of LAG3 coincides with high bacterial burdens and changes in the host type 1 helper T-cell response, and this response is not observed in nonhuman primates infected with non-MTB bacterial pathogens, nor with simian immunodeficiency virus alone.