Taylor W. Foreman

TL;DR: It is shown that aerosol immunization of macaques with the Mtb mutant in SigH (MtbΔsigH) results in significant recruitment of inducible bronchus-associated lymphoid tissue (iBALT) as well as CD4+ and CD8+ T cells expressing activation and proliferation markers to the lungs.

TL;DR: The DosR regulon modulates both the magnitude and the timing of adaptive immune responses in response to hypoxia in vivo, resulting in persistent infection and interference with the development of effective antituberculosis vaccines.

TL;DR: It is demonstrated that blockade of IDO activity reduces both clinical manifestations of tuberculosis (TB) as well as microbial and pathological correlates of the human TB syndrome in macaques, and suggests that there exists a potential for using IDO inhibition as an effective and clinically relevant host-directed therapy for TB.

TL;DR: It is reported that protective immune responses mediated by CD8+ T cells and B cells correlate with TB control, and these findings have important implications in development of both prophylactic and therapeutic measures against TB and acquired immunodeficiency syndrome.

TL;DR: It is shown that Mtb down-regulates sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)–dependent deacetylase, in monocytes/macrophages, TB animal models, and TB patients with active disease, and a potential of SIRT1 activators in designing an effective and clinically relevant host-directed therapies for TB.