N
Nader Chalhoub
Researcher at St. Jude Children's Research Hospital
Publications - 5
Citations - 2017
Nader Chalhoub is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: PTEN & PI3K/AKT/mTOR pathway. The author has an hindex of 5, co-authored 5 publications receiving 1782 citations.
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Journal ArticleDOI
PTEN and the PI3-Kinase Pathway in Cancer
Nader Chalhoub,Suzanne J. Baker +1 more
TL;DR: Current work showing cancer-relevant complexities in the regulation of PTEN and PI3K activity, potential novel functions for PTEN, and feedback regulation within the pathway are highlighted.
Journal ArticleDOI
Novel mutations target distinct subgroups of medulloblastoma
Giles W. Robinson,Matthew Parker,Tanya A. Kranenburg,Charles Lu,Charles Lu,Xiang Chen,Li Ding,Li Ding,Timothy N. Phoenix,Erin Hedlund,Lei Wei,Xiaoyan Zhu,Nader Chalhoub,Suzanne J. Baker,Robert Huether,Richard W. Kriwacki,Natasha Curley,Radhika Thiruvenkatam,Jianmin Wang,Gang Wu,Michael Rusch,Xin Hong,Xin Hong,Jared Becksfort,Pankaj Gupta,Jing Ma,John Easton,Bhavin Vadodaria,Arzu Onar-Thomas,Tong Lin,Shaoyi Li,Stanley Pounds,Steven W. Paugh,David Zhao,Daisuke Kawauchi,Martine F. Roussel,David Finkelstein,David W. Ellison,Ching C. Lau,Eric Bouffet,Tim Hassall,Tim Hassall,Sridharan Gururangan,Sridharan Gururangan,Richard J. Cohn,Richard J. Cohn,Robert S. Fulton,Robert S. Fulton,Lucinda L. Fulton,Lucinda L. Fulton,David J. Dooling,David J. Dooling,Kerri Ochoa,Kerri Ochoa,Amar Gajjar,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Jinghui Zhang,Richard J. Gilbertson +59 more
TL;DR: Modelling of mutations in mouse lower rhombic lip progenitors that generate WNT-subgroup tumours identified genes that maintain this cell lineage (DDX3X), as well as mutated genes that initiate (CDH1) or cooperate (PIK3CA) in tumorigenesis.
Journal ArticleDOI
Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency
Pierre Olivier Frappart,Youngsoo Lee,Helen R. Russell,Nader Chalhoub,Yong Dong Wang,Kenji E. Orii,Jingfeng Zhao,Naomi Kondo,Suzanne J. Baker,Peter J. McKinnon +9 more
TL;DR: The data highlight the preeminence of Ptch1 as a tumor suppressor in cerebellar granule cells and reveal other genomic events central to the genesis of medulloblastoma.
Journal ArticleDOI
Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains
TL;DR: The results show Pdk1-dependent and P DK1-independent abnormalities in Pten-deficient brains, and demonstrate cell type specific differences in feedback regulation of the ubiquitous PI3K pathway.
Journal ArticleDOI
S6k1 is not required for Pten-deficient neuronal hypertrophy.
TL;DR: A cell type-dependent role for S 6k1 in PI3K-dependent hypertrophy is revealed and it is concluded that S6k1 is not required to causehypertrophy of Pten-deficient neurons.