T
Timothy N. Phoenix
Researcher at University of Cincinnati
Publications - 51
Citations - 3562
Timothy N. Phoenix is an academic researcher from University of Cincinnati. The author has contributed to research in topics: Biology & Glioma. The author has an hindex of 17, co-authored 33 publications receiving 2903 citations. Previous affiliations of Timothy N. Phoenix include St. Jude Children's Research Hospital & Albany Medical College.
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Journal ArticleDOI
Novel mutations target distinct subgroups of medulloblastoma
Giles W. Robinson,Matthew Parker,Tanya A. Kranenburg,Charles Lu,Charles Lu,Xiang Chen,Li Ding,Li Ding,Timothy N. Phoenix,Erin Hedlund,Lei Wei,Xiaoyan Zhu,Nader Chalhoub,Suzanne J. Baker,Robert Huether,Richard W. Kriwacki,Natasha Curley,Radhika Thiruvenkatam,Jianmin Wang,Gang Wu,Michael Rusch,Xin Hong,Xin Hong,Jared Becksfort,Pankaj Gupta,Jing Ma,John Easton,Bhavin Vadodaria,Arzu Onar-Thomas,Tong Lin,Shaoyi Li,Stanley Pounds,Steven W. Paugh,David Zhao,Daisuke Kawauchi,Martine F. Roussel,David Finkelstein,David W. Ellison,Ching C. Lau,Eric Bouffet,Tim Hassall,Tim Hassall,Sridharan Gururangan,Sridharan Gururangan,Richard J. Cohn,Richard J. Cohn,Robert S. Fulton,Robert S. Fulton,Lucinda L. Fulton,Lucinda L. Fulton,David J. Dooling,David J. Dooling,Kerri Ochoa,Kerri Ochoa,Amar Gajjar,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Jinghui Zhang,Richard J. Gilbertson +59 more
TL;DR: Modelling of mutations in mouse lower rhombic lip progenitors that generate WNT-subgroup tumours identified genes that maintain this cell lineage (DDX3X), as well as mutated genes that initiate (CDH1) or cooperate (PIK3CA) in tumorigenesis.
Journal ArticleDOI
The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells
Qin Shen,Yue Wang,John T. Dimos,Christopher A. Fasano,Timothy N. Phoenix,Ihor R. Lemischka,Natalia Ivanova,Stefano Stifani,Edward E. Morrisey,Sally Temple +9 more
TL;DR: It is shown in mice that the essential timing mechanism is programmed within individual progenitor cells, and its expression depends solely on cell-intrinsic and environmental factors generated within the clonal lineage.
Journal ArticleDOI
C11orf95 – RELA fusions drive oncogenic NF-κB signalling in ependymoma
Matthew Parker,Kumarasamypet M. Mohankumar,Chandanamali Punchihewa,Ricardo Weinlich,James Dalton,Yongjin Li,Ryan P. Lee,Ruth G. Tatevossian,Timothy N. Phoenix,Radhika Thiruvenkatam,Elsie White,Bo Tang,Wilda Orisme,Kirti Gupta,Michael Rusch,Xiang Chen,Yuxin Li,Panduka Nagahawhatte,Erin Hedlund,David Finkelstein,Gang Wu,Sheila A. Shurtleff,John Easton,Kristy Boggs,Donald Yergeau,Bhavin Vadodaria,Heather L. Mulder,Jared Becksford,Pankaj Gupta,Robert Huether,Jing Ma,Guangchun Song,Amar Gajjar,Thomas E. Merchant,Frederick A. Boop,Amy A Smith,Li Ding,Charles Lu,Kerri Ochoa,David Zhao,Robert S. Fulton,Lucinda Fulton,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Douglas R. Green,Jinghui Zhang,David W. Ellison,Richard J. Gilbertson +48 more
TL;DR: The data identify a highly recurrent genetic alteration of RELA in human cancer, and the C11orf95–RELA fusion protein as a potential therapeutic target in supratentorial ependymoma.
Journal ArticleDOI
Resolving medulloblastoma cellular architecture by single-cell genomics
Volker Hovestadt,Volker Hovestadt,Kyle S. Smith,Laure Bihannic,Mariella G. Filbin,Mariella G. Filbin,Mariella G. Filbin,McKenzie Shaw,McKenzie Shaw,McKenzie Shaw,Alicia Baumgartner,Alicia Baumgartner,John C. DeWitt,John C. DeWitt,Andrew P Groves,Lisa Mayr,Hannah R. Weisman,Hannah R. Weisman,Alyssa R. Richman,Alyssa R. Richman,Marni E. Shore,Marni E. Shore,Liliana Goumnerova,Celeste Rosencrance,Robert A. Carter,Timothy N. Phoenix,Jennifer Hadley,Yiai Tong,Jim Houston,Richard A. Ashmun,Michael DeCuypere,Tanvi Sharma,Diane Flasch,Antonina Silkov,Keith L. Ligon,Keith L. Ligon,Scott L. Pomeroy,Miguel Rivera,Miguel Rivera,Orit Rozenblatt-Rosen,Orit Rozenblatt-Rosen,Jessica M. Rusert,Robert J. Wechsler-Reya,Xiao-Nan Li,Andreas Peyrl,Johannes Gojo,Dominik Kirchhofer,Daniela Lötsch,Thomas Czech,Christian Dorfer,Christine Haberler,René Geyeregger,René Geyeregger,Angela Halfmann,Charles Gawad,John Easton,Stefan M. Pfister,Stefan M. Pfister,Aviv Regev,Aviv Regev,Amar Gajjar,Brent A. Orr,Irene Slavc,Giles W. Robinson,Bradley E. Bernstein,Bradley E. Bernstein,Mario L. Suvà,Mario L. Suvà,Paul A. Northcott +68 more
TL;DR: Characterization of medulloblastoma tissues using single-cell transcriptomics shows that the different molecular subtypes consist of distinct developmental phenotypes, which provides insights into the cellular and developmental states underlying subtype-specific medullOBlastoma biology.
Journal ArticleDOI
C11orf95-rela fusions drive oncogenic nf-kb signaling in ependymoma.
Richard J. Gilbertson,Matthew Parker,Kumarasamypet M. Mohankumar,Chandanamali Punchihewa,Ricardo Weinlich,James Dalton,Yongjin Li,Ryan P. Lee,Ruth G. Tatevossian,Timothy N. Phoenix,Radhika Thiruvenkatam,Elsie White,Bo Tang,Wilda Orisme,Kirti Gupta,Michael Rusch,Xiang Chen,Yuxin Li,Panduka Nagahawhatta,Erin Hedlund,David Finkelstein,Gang Wu,Sheila A. Shurtleff,John Easton,Kristy Boggs,Donald Yergeau,Bhavin Vadodaria,Heather L. Mulder,Jared Becksford,Pankaj Gupta,Robert Huether,Jing Ma,Guangchun Song,Amar Gajjar,Thomas E. Merchant,Frederick A. Boop,Amy A Smith,Li Ding,Charles Lu,Kerri Ochoa,David Zhao,Robert S. Fulton,Lucinda L. Fulton,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Douglas R. Green,Jinghui Zhang,David W. Ellison,Richard J. Gilbertson +49 more
TL;DR: The data identify the first highly recurrent genetic alteration of RELA in human cancer, and the C11orf95-RELA fusion protein as a potential therapeutic target in supratentorial ependymoma.