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Daniela Niemeyer
Researcher at Charité
Publications - 51
Citations - 11212
Daniela Niemeyer is an academic researcher from Charité. The author has contributed to research in topics: Virus & Coronavirus. The author has an hindex of 20, co-authored 35 publications receiving 7898 citations. Previous affiliations of Daniela Niemeyer include University of Bonn & Humboldt University of Berlin.
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Journal ArticleDOI
Virological assessment of hospitalized patients with COVID-2019.
Roman Wölfel,Victor M. Corman,Wolfgang Guggemos,M Seilmaier,Sabine Zange,Marcel A. Müller,Daniela Niemeyer,Terry Jones,Terry Jones,Patrick Vollmar,Camilla Rothe,Michael Hoelscher,Tobias Bleicker,Sebastian Brünink,Julia Schneider,Rosina Ehmann,Katrin Zwirglmaier,Christian Drosten,Clemens M. Wendtner +18 more
TL;DR: Detailed virological analysis of nine cases of coronavirus disease 2019 (COVID-19) provides proof of active replication of the SARS-CoV-2 virus in tissues of the upper respiratory tract.
Journal ArticleDOI
Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response
Ilona Glowacka,Stephanie Bertram,Marcel A. Müller,Paul Allen,Elizabeth J. Soilleux,Susanne Pfefferle,Imke Steffen,Theodros Solomon Tsegaye,Yuxian He,Kerstin Gnirss,Daniela Niemeyer,Heike Schneider,Christian Drosten,Stefan Pöhlmann,Stefan Pöhlmann +14 more
TL;DR: It is shown that TMPRSS2 might promote viral spread and pathogenesis by diminishing viral recognition by neutralizing antibodies and by activating SARS S for cell-cell and virus-cell fusion.
Book ChapterDOI
Hosts and Sources of Endemic Human Coronaviruses.
TL;DR: New data suggest that HCoV-229E may actually be transferred from dromedary camels similar to Middle East respiratory syndrome (MERS) coronavirus, which provides important ecological parallels to the present prepandemic pattern of host associations of the MERS coronav virus.
Posted ContentDOI
Clinical presentation and virological assessment of hospitalized cases of coronavirus disease 2019 in a travel-associated transmission cluster
Roman Woelfel,Victor M. Corman,Wolfgang Guggemos,M Seilmaier,Sabine Zange,Marcel A Mueller,Daniela Niemeyer,Patrick Vollmar,Camilla Rothe,Michael Hoelscher,Tobias Bleicker,Bruenink S,Julia Schneider,Rosina Ehmann,Katrin Zwirglmaier,Christian Drosten,Clemens M. Wendtner +16 more
TL;DR: It is shown that COVID-19 can often present as a common cold-like illness, and SARS-CoV-2 can actively replicate in the upper respiratory tract, and is shed for a prolonged time after symptoms end, including in stool.
Journal ArticleDOI
The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors
Susanne Pfefferle,Julia Schöpf,Manfred Kögl,Caroline C. Friedel,Caroline C. Friedel,Marcel A. Müller,Javier Carbajo-Lozoya,Thorsten Stellberger,Ekatarina von Dall'Armi,Petra Herzog,Stefan Kallies,Daniela Niemeyer,Vanessa Ditt,Thomas Kuri,Roland Züst,Ksenia Pumpor,Rolf Hilgenfeld,Frank Schwarz,Ralf Zimmer,Imke Steffen,Friedemann Weber,Friedemann Weber,Volker Thiel,Georg Herrler,Heinz Jürgen Thiel,Christel Schwegmann-Weßels,Stefan Pöhlmann,Jürgen Haas,Jürgen Haas,Christian Drosten,Albrecht von Brunn +30 more
TL;DR: Overexpression of NSP1 and infection with live SARS-CoV strongly increased signalling through the Calcineurin/NFAT pathway and enhanced the induction of interleukin 2, compatible with late-stage immunopathogenicity and long-term cytokine dysregulation as observed in severe SARS cases.