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Nancy Kleckner
Researcher at Harvard University
Publications - 223
Citations - 37095
Nancy Kleckner is an academic researcher from Harvard University. The author has contributed to research in topics: Tn10 & Meiosis. The author has an hindex of 92, co-authored 217 publications receiving 34993 citations. Previous affiliations of Nancy Kleckner include Massachusetts Institute of Technology & University of California, Los Angeles.
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Journal ArticleDOI
Communication between homologous chromosomes: genetic alterations at a nuclease-hypersensitive site can alter mitotic chromatin structure at that site both in cis and in trans
Scott Keeney,Nancy Kleckner +1 more
TL;DR: This work has suggested that homology is sensed directly at the DNA level in diploid strains of the yeast Saccharomyces cerevisiae through direct physical interactions between intact DNA duplexes in nuclease‐hypersensitive regions.
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Unusual alleles of recB and recC stimulate excision of inverted repeat transposons Tn10 and Tn5.
TL;DR: Three mutations of Escherichia coli K-12, designated texA, are described that enhance excision of Tn10 and of the structurally analogous transposon Tn5; for one texA allele, excision has become dependent on RecA function as well.
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E3 ligase Hei10: a multifaceted structure-based signaling molecule with roles within and beyond meiosis
TL;DR: It is suggested that Hei10 is a unique type of structure-based signal transduction protein that integrates signals from the SC, associated recombination complexes, and the cell cycle to mediate both the development and programmed turnover/evolution of recombinations complexes via SUMOylation/ubiquitination.
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General quantitative relations linking cell growth and the cell cycle in Escherichia coli.
Hai Zheng,Yang Bai,Meiling Jiang,Taku A. Tokuyasu,Xiongliang Huang,Fajun Zhong,Yuqian Wu,Xiongfei Fu,Nancy Kleckner,Terence Hwa,Chenli Liu +10 more
TL;DR: An integral-threshold model is proposed in which the cell cycle is controlled by a licensing process, the rate of which is related in a simple way to chromosomal dynamics, which provides a quantitative basis for predictive understanding of cell growth–cell cycle relationships.
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The Escherichia coli baby cell column: a novel cell synchronization method provides new insight into the bacterial cell cycle
TL;DR: It is shown that use of ‘minutes after elution’ as a time metric permits much greater temporal resolution among sequential chromosomal events than the commonly used metric of cell size (length).