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Nancy Kleckner
Researcher at Harvard University
Publications - 223
Citations - 37095
Nancy Kleckner is an academic researcher from Harvard University. The author has contributed to research in topics: Tn10 & Meiosis. The author has an hindex of 92, co-authored 217 publications receiving 34993 citations. Previous affiliations of Nancy Kleckner include Massachusetts Institute of Technology & University of California, Los Angeles.
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Molecular cloning and characterization of the pgm gene encoding phosphoglucomutase of Escherichia coli.
Min Lu,Nancy Kleckner +1 more
TL;DR: The identification and characterization of pgm, a gene in Escherichia coli that encodes the enzyme phosphoglucomutase, specifically required for the catalysis of the interconversion of glucose 1-phosphate and glucose 6-Phosphate is reported.
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Meiotic double-strand breaks occur once per pair of (sister) chromatids and, via Mec1/ATR and Tel1/ATM, once per quartet of chromatids
TL;DR: The two types of constraints on DSB formation provide two different safeguards against recombination failure during meiosis, spreading trans inhibition can explain even spacing of total recombinational interactions and implies that establishment of interhomolog interactions and D SB formation are homeostatic processes.
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The Logic and Mechanism of Homologous Recombination Partner Choice
TL;DR: It is proposed that a Rad51/DNA filament at one DSB end captures the intact sister, creating an anchor pad, thus forcing use of the homolog, and cohesin and Dmc1 interactively modulate this extension, with program-appropriate effects.
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Escherichia coli sister chromosome separation includes an abrupt global transition with concomitant release of late-splitting intersister snaps
Mohan C. Joshi,Aude Bourniquel,Jay K. Fisher,Brian T. Ho,David Magnan,Nancy Kleckner,David Bates +6 more
TL;DR: The presented patterns imply that segregation of Escherichia coli sister chromosomes is not a smooth continuous process but involves at least one and likely, two major global transition(s) and suggest that accumulation of internal intranucleoid forces and constraining of these forces by snaps play central roles in global chromosome dynamics.
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A few of our favorite things: Pairing, the bouquet, crossover interference and evolution of meiosis.
Denise Zickler,Nancy Kleckner +1 more
TL;DR: An overview of the classical phenomenon of crossover (CO) interference is provided in an effort to bridge the gap between description on the one hand versus logic and mechanism on the other.