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Nancy Kleckner
Researcher at Harvard University
Publications - 223
Citations - 37095
Nancy Kleckner is an academic researcher from Harvard University. The author has contributed to research in topics: Tn10 & Meiosis. The author has an hindex of 92, co-authored 217 publications receiving 34993 citations. Previous affiliations of Nancy Kleckner include Massachusetts Institute of Technology & University of California, Los Angeles.
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Journal ArticleDOI
The Tn10 Synaptic Complex Can Capture a Target DNA only after Transposon Excision
Janice Sakai,Nancy Kleckner +1 more
TL;DR: Staged in vitro reactions demonstrate that a Tn10 synaptic complex can become committed to a particular target DNA molecule via a noncovalent interaction in the absence of strand transfer.
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Nearly precise excision: a new type of DNA alteration associated with the translocatable element Tn10
TL;DR: It is not yet clear, however, whether nearly precise excisions are specifically promoted by Tn10 or whether they arise during the course of normal DNA replication processes as a consequence of unusual symmetries present in the DNA sequence at the ends of Tn 10.
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Meiotic prophase roles of Rec8 in crossover recombination and chromosome structure
Sang-Wook Yoon,Min-Su Lee,Martin Xaver,Liangran Zhang,Soogil Hong,Yoon-Ju Kong,Hong-Rae Cho,Nancy Kleckner,Keun Pil Kim +8 more
TL;DR: The results suggest that Rec8's prophase function, independently of cohesin cleavage, contributes to CO-specific events in conjunction with the maintenance of homolog bias at the leptotene/zygotene transition of meiotic prophase.
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A rigorous measure of genome-wide genetic shuffling that takes into account crossover positions and Mendel's second law.
TL;DR: A rigorous measure of genome-wide shuffling that takes into account r¯, the probability that a randomly chosen pair of loci shuffles their alleles in a gamete, finds that r¯ in humans is close to its maximum possible value of one-half and that this high value is largely due to independent assortment.
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Interference-mediated synaptonemal complex formation with embedded crossover designation
TL;DR: Evidence is presented in the fungus Sordaria macrospora that crossover interference is part of a broader pattern that includes synaptonemal complex (SC) nucleation, which ensures that SC forms regularly along the entire length of the chromosome as required for the maintenance of homolog pairing.