Naoki Ikari

TL;DR: The results suggest that intraductal tubulopapillary neoplasm has distinguishing genetic characteristics and some of these mutated genes are potentially targetable.

TL;DR: Results indicate that rare germline variations in BRCA pathway genes could be found more frequently than previously anticipated and, more importantly, potentially deleterious mutations of them could be a favorable prognostic factor in patients with resectable PDACs.

TL;DR: The p53 pathway may facilitate the development of biomarkers and therapeutic approaches to treat gastric cancer metastases to the liver, and Immunohistochemical analyses showed aberrant p53 expression in tumors with TP53 mutations.

TL;DR: This case of human epidermal growth factor receptor-2 (HER2)-positive gastric cancer with paraaortic lymph node metastasis is reported, suggesting that, due to intra-tumor heterogeneity, the risks presented by remnant HER2-negative cancer cells persist despite trastuzumab therapy.

TL;DR: In this article, a system for identifying and testing genotype-oriented targeted drugs for pancreatobiliary cancers by combining exome sequencing and organoid culture of primary tumours was established.