Journal ArticleDOI
Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma
Olca Basturk,Michael F. Berger,Hiroshi Yamaguchi,Volkan Adsay,Gokce Askan,Umesh Bhanot,Ahmet Zehir,Fátima Carneiro,Seung-Mo Hong,Giuseppe Zamboni,Esra Dikoglu,Vaidehi Jobanputra,Kazimierz O. Wrzeszczynski,Serdar Balci,Peter J. Allen,Naoki Ikari,Shoko Takeuchi,Hiroyuki Akagawa,Atsushi Kanno,Tooru Shimosegawa,Takanori Morikawa,Fuyuhiko Motoi,Michiaki Unno,Ryota Higuchi,Masakazu Yamamoto,Kyoko Shimizu,Toru Furukawa,David S. Klimstra +27 more
TLDR
The results suggest that intraductal tubulopapillary neoplasm has distinguishing genetic characteristics and some of these mutated genes are potentially targetable.About:
This article is published in Modern Pathology.The article was published on 2017-08-04. It has received 52 citations till now. The article focuses on the topics: Pancreatic Intraductal Tubulopapillary Neoplasm & Pancreatic Intraductal Neoplasm.read more
Citations
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Integrative Genomics Viewer
James T. Robinson,Helga Thorvaldsdottir,Wendy Winckler,Mitchell Guttman,Eric S. Lander,Eric S. Lander,Gad Getz,Jill P. Mesirov +7 more
TL;DR: The sheer volume and scope of data posed by this flood of data pose a significant challenge to the development of efficient and intuitive visualization tools able to scale to very large data sets and to flexibly integrate multiple data types, including clinical data.
Journal ArticleDOI
Pancreatic Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells
TL;DR: The development of mouse models of PDAC has greatly contributed to the understanding of the molecular and cellular mechanisms through which driver genes contribute to pancreatic cancer development, and suggested that a minority cell population is responsible for initiation and maintenance of pancreatic adenocarcinomas.
Journal ArticleDOI
Early detection of pancreatic cancer using DNA-based molecular approaches.
Aatur D. Singhi,Laura D. Wood +1 more
TL;DR: In this paper, the authors discuss and focus on the pathological and molecular features of precancerous lesions of the pancreas, including pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasm, which are target lesions of early detection approaches.
Journal ArticleDOI
Histopathological evaluation of minor salivary gland papillary-cystic tumours: focus on genetic alterations in sialadenoma papilliferum and intraductal papillary mucinous neoplasm.
Masato Nakaguro,Makoto Urano,Ikuko Ogawa,Hideaki Hirai,Yoshinari Yamamoto,Hiroshi Yamaguchi,Maki Tanigawa,Jun Matsubayashi,Hiroshi Hirano,Junji Shibahara,Yuichiro Tada,Toyonori Tsuzuki,Yasuo Okada,Yuichiro Sato,Kenichiro Ikeda,Aoi Sukeda,Yumi Honda,Yoshiki Mikami,Toshitaka Nagao +18 more
TL;DR: The histological characteristics of minor salivary gland tumours are delineated and further mutational aspects with a particular focus on sialadenoma papilliferum (SP) and intraductal papillary mucinous neoplasm (IPMN).
References
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Heng Li,Richard Durbin +1 more
TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
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The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
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TL;DR: The GATK programming framework enables developers and analysts to quickly and easily write efficient and robust NGS tools, many of which have already been incorporated into large-scale sequencing projects like the 1000 Genomes Project and The Cancer Genome Atlas.
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Integrative genomics viewer
James T. Robinson,Helga Thorvaldsdottir,Wendy Winckler,Mitchell Guttman,Eric S. Lander,Eric S. Lander,Gad Getz,Jill P. Mesirov +7 more
TL;DR: In this article, the authors present an approach for efficient and intuitive visualization tools able to scale to very large data sets and to flexibly integrate multiple data types, including clinical data.
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A framework for variation discovery and genotyping using next-generation DNA sequencing data
Mark A. DePristo,Eric Banks,Ryan Poplin,Kiran V. Garimella,Jared Maguire,Christopher Hartl,Anthony A. Philippakis,Anthony A. Philippakis,Anthony A. Philippakis,Guillermo del Angel,Manuel A. Rivas,Manuel A. Rivas,Matt Hanna,Aaron McKenna,Timothy Fennell,Andrew Kernytsky,Andrey Sivachenko,Kristian Cibulskis,Stacey Gabriel,David Altshuler,David Altshuler,Mark J. Daly,Mark J. Daly +22 more
TL;DR: A unified analytic framework to discover and genotype variation among multiple samples simultaneously that achieves sensitive and specific results across five sequencing technologies and three distinct, canonical experimental designs is presented.
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A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3
Pablo Cingolani,Adrian E. Platts,Le Lily Wang,M. Coon,Tung T. Nguyen,Luan Wang,Susan Land,Xiangyi Lu,Douglas M. Ruden +8 more
TL;DR: It appears that the 5′ and 3′ UTRs are reservoirs for genetic variations that changes the termini of proteins during evolution of the Drosophila genus.
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