N
Naoki Ito
Researcher at Foundation for Biomedical Research
Publications - 32
Citations - 1788
Naoki Ito is an academic researcher from Foundation for Biomedical Research. The author has contributed to research in topics: Skeletal muscle & Muscle hypertrophy. The author has an hindex of 17, co-authored 32 publications receiving 1419 citations. Previous affiliations of Naoki Ito include Fujifilm Holdings Corporation & Tokyo Institute of Technology.
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Journal ArticleDOI
Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle
Noriaki Shimizu,Noritada Yoshikawa,Naoki Ito,Takako Maruyama,Yuko Suzuki,Sin Ichi Takeda,Jun Nakae,Yusuke Tagata,Shinobu Nishitani,Kenji Takehana,Motoaki Sano,Keiichi Fukuda,Makoto Suematsu,Chikao Morimoto,Hirotoshi Tanaka +14 more
TL;DR: It is shown that direct target genes of the glucocorticoid receptor (GR) in skeletal muscle, i.e., REDD1 and KLF15 inhibits mTOR activity, but via a distinct mechanism involving BCAT2 gene activation, and GR is a liaison involving a variety of downstream molecular cascades toward muscle atrophy.
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Activation of calcium signaling through Trpv1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy
TL;DR: Findings identify nitric oxide, peroxynitrite and [Ca2+]i as the crucial mediators that convert a mechanical load into an intracellular signaling pathway and lead to suggest that TRPV1 could be a new therapeutic target for treating muscle atrophy.
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Identification of muscle-specific microRNAs in serum of muscular dystrophy animal models: promising novel blood-based markers for muscular dystrophy.
Hideya Mizuno,Akinori Nakamura,Yoshitsugu Aoki,Naoki Ito,Soichiro Kishi,Kazuhiro Yamamoto,Masayuki Sekiguchi,Shin'ichi Takeda,Kazuo Hashido +8 more
TL;DR: This study quantified the expression levels of miRNAs in serum of the dystrophin-deficient muscular dystrophy mouse model, mdx, and the canine X-linked muscular Dystrophy in Japan dog model, CXMDJ, by real-time PCR and found that the serum levels of several muscle-specific mi RNAs are increased in both mdx and CX MDJ.
Journal ArticleDOI
C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia.
Yoshitsugu Aoki,Raquel Manzano,Yi Lee,Ruxandra Dafinca,M Aoki,Andrew G. L. Douglas,Miguel A. Varela,Chaitra Sathyaprakash,Jakub Scaber,Paola Barbagallo,Pieter Vader,Pieter Vader,Imre Mäger,Kariem Ezzat,Kariem Ezzat,Martin R Turner,Naoki Ito,Samanta Gasco,Norihiko Ohbayashi,Samir El Andaloussi,Samir El Andaloussi,Shin'ichi Takeda,Mitsunori Fukuda,Kevin Talbot,Matthew J.A. Wood +24 more
TL;DR: A novel mechanism arising due to the interaction of C9ORF72 with the RAB7L1 GTPase to regulate vesicle trafficking is identified highlighting the molecular regulation of intracellular and extracellular vesicles trafficking as an important pathway in C9ALS/FTD pathogenesis.
Journal ArticleDOI
A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling
Noriaki Shimizu,Takako Maruyama,Noritada Yoshikawa,Ryo Matsumiya,Yanxia Ma,Naoki Ito,Yuki Tasaka,Akiko Kuribara-Souta,Keishi Miyata,Yuichi Oike,Stefan Berger,Günther Schütz,Shin'ichi Takeda,Hirotoshi Tanaka +13 more
TL;DR: This work demonstrates that the resulting depletion of plasma alanine serves as a cue to increase plasma levels of fibroblast growth factor 21 and activates liver-fat communication, leading to the activation of lipolytic genes in adipose tissues.