N
Naotaka Hamasaki
Researcher at Kyushu University
Publications - 140
Citations - 7067
Naotaka Hamasaki is an academic researcher from Kyushu University. The author has contributed to research in topics: Mitochondrial DNA & Membrane protein. The author has an hindex of 41, co-authored 140 publications receiving 6682 citations. Previous affiliations of Naotaka Hamasaki include Centre national de la recherche scientifique & Nagasaki International University.
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Journal ArticleDOI
Oxidative Stress Mediates Tumor Necrosis Factor-α–Induced Mitochondrial DNA Damage and Dysfunction in Cardiac Myocytes
Nobuhiro Suematsu,Hiroyuki Tsutsui,Jing Wen,Dongchon Kang,Masaki Ikeuchi,Tomomi Ide,Shunji Hayashidani,Tetsuya Shiomi,Toru Kubota,Naotaka Hamasaki,Akira Takeshita +10 more
TL;DR: The intimate link between TNF-&agr;, ROS, and mtDNA damage might play an important role in myocardial remodeling and failure.
Journal ArticleDOI
Human mitochondrial DNA is packaged with TFAM
Tanfis Istiaq Alam,Tomotake Kanki,Tsuyoshi Muta,Koutarou Ukaji,Yoshito Abe,Hiroshi Nakayama,Koji Takio,Naotaka Hamasaki,Dongchon Kang +8 more
TL;DR: Results suggest that human mtDNA is packaged with TFAM, a member of the high mobility group proteins, which is abundant enough to wrap mtDNA entirely.
Journal ArticleDOI
Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma.
Hiromichi Mitsuyasu,Kenji Izuhara,Xiao-Quan Mao,Pei Song Gao,Yojiro Arinobu,Tadao Enomoto,M. Kawai,S. Sasaki,Y. Dake,Naotaka Hamasaki,Taro Shirakawa,J. M. Hopkin +11 more
TL;DR: Ile50 associated with atopic asthma but not with non-atopic asthma; Ile50 specifically and significantly associated with raised total serum IgE levels and mite-specific IgE; the association with atopy was especially strong in children.
Journal ArticleDOI
Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functions.
TL;DR: Overexpression of human TFAM in mice increases the amount of mitochondrial DNA and dramatically ameliorates the cardiac dysfunctions caused by myocardial infarction.
Journal ArticleDOI
Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA.
Tomotake Kanki,Kippei Ohgaki,Martina Gaspari,Claes M. Gustafsson,Atsushi Fukuoh,Narie Sasaki,Naotaka Hamasaki,Dongchon Kang +7 more
TL;DR: An architectural role for TFAM in the maintenance of mtDNA in addition to its role in transcription activation is discussed, suggesting that TFAM-ΔC is as competent in maintaining mtDNA as endogenous TFAM under these conditions.