Y
Y. Dake
Researcher at University of Oxford
Publications - 9
Citations - 1055
Y. Dake is an academic researcher from University of Oxford. The author has contributed to research in topics: Immunoglobulin E & Atopy. The author has an hindex of 9, co-authored 9 publications receiving 1042 citations.
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Journal ArticleDOI
Genetic variants of IL-13 signalling and human asthma and atopy
Andrea Heinzmann,X. Q. Mao,Mina Akaiwa,R. T. Kreomer,Peisong Gao,Koichi Ohshima,R. Umeshita,R. Umeshita,Yoshito Abe,Sandra Braun,Tetsuji Yamashita,Mark H. Roberts,Rie Sugimoto,Kazuhiko Arima,Yojiro Arinobu,Bin Yu,S. Kruse,Tadao Enomoto,Y. Dake,M. Kawai,S. Shimazu,S. Sasaki,Chaker N. Adra,M. Kitaichi,Hiroshi Inoue,Kohei Yamauchi,Nobukazu Tomichi,Fumihiko Kurimoto,Naotaka Hamasaki,Julian M. Hopkin,Kenji Izuhara,T. Shirakawa,Klaus A. Deichmann +32 more
TL;DR: Detailed molecular modelling analyses indicate that residue 110 of IL-13, the site of the charge-modifying variants Arg and Gln, is important in the internal constitution of the ligand and crucial in ligand-receptor interaction, likely to be important promoters of human asthma.
Journal ArticleDOI
Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma.
Hiromichi Mitsuyasu,Kenji Izuhara,Xiao-Quan Mao,Pei Song Gao,Yojiro Arinobu,Tadao Enomoto,M. Kawai,S. Sasaki,Y. Dake,Naotaka Hamasaki,Taro Shirakawa,J. M. Hopkin +11 more
TL;DR: Ile50 associated with atopic asthma but not with non-atopic asthma; Ile50 specifically and significantly associated with raised total serum IgE levels and mite-specific IgE; the association with atopy was especially strong in children.
Journal ArticleDOI
Imbalance production between interleukin-1beta (IL-1beta) and IL-1 receptor antagonist (IL-1Ra) in bronchial asthma.
X. Q. Mao,M. Kawai,Tetsuji Yamashita,Tadao Enomoto,Y. Dake,Sei Sasaki,Yoko Kataoka,Takayuki Fukuzumi,Kaoru Endo,Hozumi Sano,Toshiyuki Aoki,Fumihiko Kurimoto,Chaker N. Adra,T. Shirakawa,T. Shirakawa,Julian M. Hopkin +15 more
TL;DR: Findings suggest that dysregulation of IL-1beta/IL-1Ra, probably due to interaction between epithelium and immuno-competent cells in the airway, is important in asthma inflammation.
Journal ArticleDOI
Negative association between asthma and variants of CC16(CC10) on chromosome 11q13 in British and Japanese populations
Pei Song Gao,Xiao-Quan Mao,M. Kawai,Tadao Enomoto,S. Sasaki,O. Tanabe,Kunihiko Yoshimura,S. R. Shaldon,Y. Dake,Hiroya Kitano,P. Coull,Taro Shirakawa,J. M. Hopkin +12 more
TL;DR: No significant association was found between asthma and CC16 genotypes, irrespective of atopic status in these two populations, suggesting that CC16 might not be the major locus for asthma on 11q13.
Journal ArticleDOI
Association between Variants of Mast Cell Chymase Gene and Serum IgE Levels in Eczema
X. Q. Mao,T. Shirakawa,T. Enomoto,S. Shimazu,Y. Dake,Hiroya Kitano,Akihito Hagihara,J.M. Hopkin +7 more
TL;DR: MCC genotypes showed a strong association with eczema, but not with asthma and rhinitis, and independent of IgE responsiveness when total serum IgE of less than 500 IU/ml, MCC variants may play an important role in inflammatory skin disorders.