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Shunji Hayashidani
Researcher at Kyushu University
Publications - 25
Citations - 4574
Shunji Hayashidani is an academic researcher from Kyushu University. The author has contributed to research in topics: Heart failure & Ventricular remodeling. The author has an hindex of 19, co-authored 24 publications receiving 4345 citations. Previous affiliations of Shunji Hayashidani include Massachusetts Institute of Technology.
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Journal ArticleDOI
Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction.
Tomomi Ide,Hiroyuki Tsutsui,Shunji Hayashidani,Dongchon Kang,Nobuhiro Suematsu,Kei-ichiro Nakamura,Hideo Utsumi,Naotaka Hamasaki,Akira Takeshita +8 more
TL;DR: It is hypothesized that ROS may induce mitochondrial DNA (mtDNA) damage, which leads to defects of mtDNA-encoded gene expression and respiratory chain complex enzymes and thus may contribute to the progression of left ventricular remodeling and failure after myocardial infarction.
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Direct Evidence for Increased Hydroxyl Radicals Originating From Superoxide in the Failing Myocardium
Tomomi Ide,Hiroyuki Tsutsui,Shintaro Kinugawa,Nobuhiro Suematsu,Shunji Hayashidani,Kazuhiro Ichikawa,Hideo Utsumi,Youji Machida,Kensuke Egashira,Akira Takeshita +9 more
TL;DR: There was a significant positive relation between myocardial ROS level and left ventricular contractile dysfunction and, in the failing myocardium, *OH was produced as a reactive product of *O(2)(-) and H(2)O( 2), which might play an important role inleft ventricular failure.
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Oxidative Stress Mediates Tumor Necrosis Factor-α–Induced Mitochondrial DNA Damage and Dysfunction in Cardiac Myocytes
Nobuhiro Suematsu,Hiroyuki Tsutsui,Jing Wen,Dongchon Kang,Masaki Ikeuchi,Tomomi Ide,Shunji Hayashidani,Tetsuya Shiomi,Toru Kubota,Naotaka Hamasaki,Akira Takeshita +10 more
TL;DR: The intimate link between TNF-&agr;, ROS, and mtDNA damage might play an important role in myocardial remodeling and failure.
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Treatment With Dimethylthiourea Prevents Left Ventricular Remodeling and Failure After Experimental Myocardial Infarction in Mice Role of Oxidative Stress
Shintaro Kinugawa,Hiroyuki Tsutsui,Shunji Hayashidani,Tomomi Ide,Nobuhiro Suematsu,Shinji Satoh,Hideo Utsumi,Akira Takeshita +7 more
TL;DR: The attenuation of increased myocardial ROS and metalloproteinase activity with DMTU may contribute, at least in part, to its beneficial effects on LV remodeling and failure.
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Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction.
Shunji Hayashidani,Hiroyuki Tsutsui,Masaki Ikeuchi,Tetsuya Shiomi,Hidenori Matsusaka,Toru Kubota,Kyoko Imanaka-Yoshida,Takeshi Itoh,Akira Takeshita +8 more
TL;DR: The inhibition of MMP-2 activation may be a potentially useful therapeutic strategy to manage post-MI hearts and contribute to an early cardiac rupture as well as late LV remodeling after MI.