N
Narayan V. Iyer
Researcher at Johns Hopkins University School of Medicine
Publications - 16
Citations - 10911
Narayan V. Iyer is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Hypoxia-Inducible Factor 1 & Transcription factor. The author has an hindex of 15, co-authored 16 publications receiving 10366 citations. Previous affiliations of Narayan V. Iyer include Johns Hopkins University & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1.
Jo A. Forsythe,Bing-Hua Jiang,Narayan V. Iyer,Faton Agani,Sandra W. Leung,Robert D. Koos,Gregg L. Semenza +6 more
TL;DR: HIF-1 is implicate in the activation of VEGF transcription in hypoxic cells and this work demonstrates the involvement of Hif-1 in theactivation of V EGF transcription.
Journal ArticleDOI
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α
Narayan V. Iyer,Lori E. Kotch,Faton Agani,Sandra W. Leung,Erik Laughner,Roland H. Wenger,Max Gassmann,John D. Gearhart,Ann M. Lawler,Aimee Y. Yu,Gregg L. Semenza +10 more
TL;DR: It is demonstrated that HIF-1alpha is a master regulator of cellular and developmental O2 homeostasis in Hif1a-/- embryos that manifested neural tube defects, cardiovascular malformations, and marked cell death within the cephalic mesenchyme.
Journal ArticleDOI
Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia
Patty J. Lee,Bing-Hua Jiang,Beek Yoke Chin,Narayan V. Iyer,Jawed Alam,Gregg L. Semenza,Augustine M.K. Choi +6 more
TL;DR: Data demonstrate that hypoxia induces HO-1 expression in animal tissues and cell cultures and implicate HIF-1 in this response.
Journal Article
Reciprocal Positive Regulation of Hypoxia-inducible Factor 1α and Insulin-like Growth Factor 2
TL;DR: It is demonstrated that insulin, insulin-like growth factor (IGF)-1, and IGF-2 induce expression of HIF-1alpha, which is required for expression of genes encoding IGF- 2, IGF-binding protein (IGfBP)-2 and IGFBP-3.
Journal ArticleDOI
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
Aimee Y. Yu,Larissa A. Shimoda,Narayan V. Iyer,David L. Huso,Xing Sun,Rita McWilliams,Terri H. Beaty,James S.K. Sham,Charles M. Wiener,J. T. Sylvester,Gregg L. Semenza +10 more
TL;DR: It is shown that partial HIF-1alpha deficiency has significant effects on multiple systemic responses to chronic hypoxia, and significantly greater weight loss compared with wild-type littermates.