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Natasha Christie
Researcher at University of Toronto
Publications - 8
Citations - 405
Natasha Christie is an academic researcher from University of Toronto. The author has contributed to research in topics: Virus & Infectivity. The author has an hindex of 5, co-authored 8 publications receiving 172 citations.
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Journal ArticleDOI
Detection of SARS-CoV-2 Viral Particles Using Direct, Reagent-Free Electrochemical Sensing.
Hanie Yousefi,Alam Mahmud,Dingran Chang,Jagotamoy Das,Surath Gomis,Jenise B. Chen,Hansen Wang,Terek Been,Lily Yip,Eric A. Coomes,Zhijie Li,Samira Mubareka,Allison McGeer,Natasha Christie,Scott D. Gray-Owen,Alan Cochrane,James M. Rini,Edward H. Sargent,Shana O. Kelley +18 more
TL;DR: In this article, a reagent-free method for direct detection of SARS-CoV-2 was proposed using an analyte-binding antibody displayed on a negatively charged DNA linker that also features a tethered redox probe.
Journal ArticleDOI
Isolation, Sequence, Infectivity, and Replication Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2.
Arinjay Banerjee,Arinjay Banerjee,Jalees A. Nasir,Patrick Budylowski,Lily Yip,Patryk Aftanas,Natasha Christie,Ayoob Ghalami,Kaushal Baid,Amogelang R. Raphenya,Jeremy A. Hirota,Matthew S. Miller,Allison McGeer,Mario A. Ostrowski,Robert A. Kozak,Andrew G. McArthur,Karen L. Mossman,Samira Mubareka +17 more
TL;DR: It is confirmed that human primary peripheral blood mononuclear cells are not permissive for SARS-CoV-2, making it essential to monitor single-nucleotide polymorphisms in the virus and to continue to isolate circulating viruses to determine viral genotype and phenotype.
Posted ContentDOI
Detection of SARS-CoV-2 Viral Particles using Direct, Reagent-Free Electrochemical Sensing
Hanie Yousefi,Alam Mahmud,Dingran Chang,Jagotamoy Das,Surath Gomis,Jenise B. Chen,Hansen Wang,Terek Been,Lily Yip,Eric A. Coomes,Zhijie Li,Samira Mubareka,Allison McGeer,Natasha Christie,Scott D. Gray-Owen,Alan Cochrane,James M. Rini,Edward H. Sargent,Shana O. Kelley +18 more
TL;DR: Using an electrochemical readout method that requires no external reagents, the SARS-CoV-2 virus in the saliva of infected patients is detected using a molecular sensor tethered to the surface of a gold electrode that contains an antibody, specific to the target of interest.
Journal ArticleDOI
Enhancement of HIV-specific CD8 T cell responses by dual costimulation with CD80 and CD137L.
Jacob Bukczynski,Tao Wen,Chao Wang,Natasha Christie,Jean-Pierre Routy,Mohamed Rachid Boulassel,Colin Kovacs,Kelly S. MacDonald,Kelly S. MacDonald,Mario A. Ostrowski,Rafick Pierre Sekaly,Nicole F. Bernard,Tania H. Watts +12 more
TL;DR: Costimulation with either CD137L (4-1BBL) or CD80 (B7.1) enhanced the Ag-specific expansion and acquisition of effector function by HIV-specific memory CD8 T cells and represent a promising combination for therapeutic vaccination for HIV.
Journal ArticleDOI
Viral fitness implications of variation within an immunodominant CD8+ T-cell epitope of HIV-1
Natasha Christie,David O. Willer,David O. Willer,Michael A. Lobritz,Jacqueline K. Chan,Jacqueline K. Chan,Eric J. Arts,Mario A. Ostrowski,Mario A. Ostrowski,Alan Cochrane,Mark A. Luscher,Kelly S. MacDonald,Kelly S. MacDonald +12 more
TL;DR: Research reveals that there are multiple SL9 variants that are well tolerated virologically but fail to arise in vivo, and assumptions regarding the balance of immune and viral selective pressures on this immunodominant epitope sequence need to be reassessed.