M
Michael A. Lobritz
Researcher at Case Western Reserve University
Publications - 32
Citations - 4598
Michael A. Lobritz is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Virus & Gene. The author has an hindex of 24, co-authored 31 publications receiving 3710 citations. Previous affiliations of Michael A. Lobritz include Wyss Institute for Biologically Inspired Engineering & Hoffmann-La Roche.
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Journal ArticleDOI
Antibiotics induce redox-related physiological alterations as part of their lethality
Daniel J. Dwyer,Peter Belenky,Jason H. Yang,I. Cody MacDonald,Jeffrey D. Martell,Noriko Takahashi,Clement T Y Chan,Michael A. Lobritz,Dana Braff,Eric G. Schwarz,Jonathan D. Ye,Mekhala Pati,Maarten Vercruysse,Paul S. Ralifo,Kyle R. Allison,Ahmad S. Khalil,Alice Y. Ting,Graham C. Walker,James J. Collins +18 more
TL;DR: This work provides direct evidence that, downstream of their target-specific interactions, bactericidal antibiotics induce complex redox alterations that contribute to cellular damage and death, thus supporting an evolving, expanded model of antibiotic lethality.
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Antibiotic efficacy is linked to bacterial cellular respiration
Michael A. Lobritz,Peter Belenky,Caroline B. M. Porter,Arnaud Gutierrez,Arnaud Gutierrez,Jason H. Yang,Jason H. Yang,Eric G. Schwarz,Daniel J. Dwyer,Ahmad S. Khalil,Ahmad S. Khalil,James J. Collins +11 more
TL;DR: It is shown that antibiotics perturb the metabolic state of bacteria and that the metabolicState of bacteria impacts antibiotic efficacy, and that bactericidal activity can be arrested by attenuated respiration and potentiated by accelerated respiration.
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Microbial Persistence and the Road to Drug Resistance
TL;DR: Findings raise the possibility that persisters behave as an evolutionary reservoir from which resistant organisms can emerge, and the need for clinically useful persister-eradication strategies is raised.
Journal ArticleDOI
Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage
Peter Belenky,Peter Belenky,Jonathan D. Ye,Caroline B. M. Porter,Caroline B. M. Porter,Caroline B. M. Porter,Nadia R. Cohen,Nadia R. Cohen,Michael A. Lobritz,Thomas C. Ferrante,Saloni R. Jain,Saloni R. Jain,Benjamin J. Korry,Eric G. Schwarz,Graham C. Walker,James J. Collins,James J. Collins,James J. Collins +17 more
TL;DR: In this paper, the metabolome of Escherichia coli was profiled after treatment with three different classes of bactericidal antibiotics (?-lactams, aminoglycosides, quinolones).
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HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphocyte Recognition.
Toshiyuki Miura,Mark A. Brockman,Arne Schneidewind,Michael A. Lobritz,Florencia Pereyra,Almas Rathod,Brian L. Block,Zabrina L. Brumme,Chanson J. Brumme,Brett Baker,Alissa C. Rothchild,Bin Li,Alicja Trocha,Alicja Trocha,Emily Cutrell,Nicole Frahm,Christian Brander,Ildiko Toth,Eric J. Arts,Todd M. Allen,Bruce D. Walker,Bruce D. Walker +21 more
TL;DR: A dual mechanism for durable control of HIV replication is suggested, consisting of viral fitness loss resulting from CTL escape mutations together with strong CD8 T-cell immune responses to the arising variant epitopes.