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Nattapon Panupinthu
Researcher at University of Texas MD Anderson Cancer Center
Publications - 14
Citations - 2306
Nattapon Panupinthu is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Lysophosphatidic acid & Autotaxin. The author has an hindex of 11, co-authored 12 publications receiving 1981 citations. Previous affiliations of Nattapon Panupinthu include Mahidol University & University of Texas Health Science Center at Houston.
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Journal ArticleDOI
Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
Fa-Xing Yu,Bin Zhao,Nattapon Panupinthu,Jenna L. Jewell,Ian Lian,Lloyd H. Wang,Jiagang Zhao,Hai-Xin Yuan,Karen Tumaneng,Hairi Li,Xiang-Dong Fu,Gordon B. Mills,Kun-Liang Guan +12 more
TL;DR: This study identifies extracellular diffusible signals that modulate the Hippo pathway and also establishes the hippo-YAP pathway as a critical signaling branch downstream of GPCR.
Journal ArticleDOI
Growth of Triple-Negative Breast Cancer Cells Relies upon Coordinate Autocrine Expression of the Proinflammatory Cytokines IL-6 and IL-8
Zachary C. Hartman,Graham M. Poage,Petra den Hollander,Anna Tsimelzon,Jamal Hill,Nattapon Panupinthu,Yun Zhang,Abhijit Mazumdar,Susan G. Hilsenbeck,Gordon B. Mills,Powel H. Brown +10 more
TL;DR: A Cox multivariable analysis of patient specimens revealed that IL-6 and IL-8 expression predicted patient survival times, offering a rationale for dual inhibition of IL- 6/IL-8 signaling as a therapeutic strategy to improve outcomes for patients with TNBCs.
Journal ArticleDOI
Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression.
S. Y. Park,Kang Jin Jeong,Nattapon Panupinthu,Shuangxing Yu,Jangsoon Lee,Jeung Whan Han,Ju-Ock Kim,Ju Seog Lee,Jaeku Kang,Chang Gyo Park,Gordon B. Mills,Hoi Young Lee +11 more
TL;DR: A mechanistic cascade of ATX-producing LPA with LPA activating LPA1 and inducing MMP-9 through coordinate activation of the PI3K and the p38 MPAK signaling cascades is demonstrated, providing novel biomarkers and potential therapeutic targets for HCC.
Journal ArticleDOI
Lysophosphatidic acid production and action: critical new players in breast cancer initiation and progression
TL;DR: The focus of research now turns to understanding the mechanisms by which ATX and LPA promote mammary tumourigenesis and metastasis and targeting the ATX–LPA signalling axis for drug development may further improve outcomes in patients with breast cancer.
Journal ArticleDOI
ATX-LPA receptor axis in inflammation and cancer
TL;DR: Using transgenic mice expressing either an LPA receptor or ATX, it is demonstrated that the ATX-LPA receptor axis plays a causal role in breast tumorigenesis and cancerrelated inflammation, further validating the ATx-Lpa receptor axis as a rich therapeutic target in cancer.