Neal A.L. Cody

TL;DR: The spectrum of RBP binding throughout the transcriptome and the connections between these interactions and various aspects of RNA biology, including RNA stability, splicing regulation and RNA localization are described.

TL;DR: The muscle-blind-like (Mbnl) family of RNA-binding proteins plays important roles in muscle and eye development and in myotonic dystrophy (DM), in which expanded CUG or CCUG repeats functionally deplete Mbnl proteins as mentioned in this paper.

TL;DR: The mapping and characterization of RNA elements recognized by a large collection of human RBPs in K562 and HepG2 cells are described, expanding the catalog of functional elements encoded in the human genome by addition of a large set of elements that function at the RNA level through interaction with RBPs.

TL;DR: Assessment of the prevalence and conservation of RNA asymmetric distribution on a transcriptome-wide scale in Drosophila and human cells and of fraction-specific mRNA populations reveals that the majority of cellular RNA species are asymmetrically distributed, in patterns that are broadly conserved evolutionarily.

TL;DR: This review discusses the diverse biological functions, advantages, and mechanisms of mRNA localization that have been characterized to date and discusses recent technological innovations in RNA imaging and functional genomics methods that will undoubtedly provide powerful new strategies for the elucidation of mRNA trafficking pathways.