S
Sita Reddy
Researcher at University of Southern California
Publications - 62
Citations - 3850
Sita Reddy is an academic researcher from University of Southern California. The author has contributed to research in topics: Myotonic dystrophy & MBNL1. The author has an hindex of 32, co-authored 61 publications receiving 3630 citations. Previous affiliations of Sita Reddy include Massachusetts Institute of Technology.
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Journal ArticleDOI
Transcriptome-wide Regulation of Pre-mRNA Splicing and mRNA Localization by Muscleblind Proteins
Eric T. Wang,Neal A.L. Cody,Sonali P. Jog,Michela Biancolella,Thomas T. Wang,Daniel J. Treacy,Shujun Luo,Gary P. Schroth,David E. Housman,Sita Reddy,Eric Lécuyer,Christopher B. Burge +11 more
TL;DR: The muscle-blind-like (Mbnl) family of RNA-binding proteins plays important roles in muscle and eye development and in myotonic dystrophy (DM), in which expanded CUG or CCUG repeats functionally deplete Mbnl proteins as mentioned in this paper.
Journal ArticleDOI
Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy.
Sita Reddy,Daniel J. Smith,Mark M. Rich,John Leferovich,Patricia Anne Reilly,Brigid M. Davis,Khoa D. Tran,Helen Rayburn,Roderick T. Bronson,Didier Cros,Rita J. Balice-Gordon,David E. Housman +11 more
TL;DR: The results indicate that D MPK may be necessary for the maintenance of skeletal muscle structure and function and suggest that a decrease in DMPK levels may contribute to DM pathology.
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RNA CUG Repeats Sequester CUGBP1 and Alter Protein Levels and Activity of CUGBP1
TL;DR: It is demonstrated that the expansion of CUG repeats in DM affects RNA-binding proteins and leads to alteration in RNA processing.
Journal ArticleDOI
MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1.
TL;DR: In this paper, small interfering RNA-mediated down-regulation of MBNL1, MBNL2, and CUG-BP in DM1 myoblasts was shown to lead to abnormal splicing of the insulin receptor (IR) RNA.
Journal ArticleDOI
DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model
Charles I. Berul,Colin T. Maguire,Mark Aronovitz,Jessica Greenwood,Carol L. Miller,Josef Gehrmann,David E. Housman,Michael E. Mendelsohn,Sita Reddy +8 more
TL;DR: It is demonstrated that D MPK dosage is a critical element modulating cardiac conduction integrity and conclusively link haploinsufficiency of DMPK with cardiac disease in myotonic dystrophy.