Xiaofeng Wang

TL;DR: The spectrum of RBP binding throughout the transcriptome and the connections between these interactions and various aspects of RNA biology, including RNA stability, splicing regulation and RNA localization are described.

TL;DR: The mapping and characterization of RNA elements recognized by a large collection of human RBPs in K562 and HepG2 cells are described, expanding the catalog of functional elements encoded in the human genome by addition of a large set of elements that function at the RNA level through interaction with RBPs.

TL;DR: A validated repository of 438 commercially available antibodies that interrogate 365 unique RBPs are developed that can characterize subcellular RBP localization and are invaluable to the broad scientific community.

TL;DR: Assessment of the prevalence and conservation of RNA asymmetric distribution on a transcriptome-wide scale in Drosophila and human cells and of fraction-specific mRNA populations reveals that the majority of cellular RNA species are asymmetrically distributed, in patterns that are broadly conserved evolutionarily.

TL;DR: It is shown that nuclear retention involves a Chk2-dependent mechanism of mRNA nuclear retention that is induced by DNA damage and prevents the translation of specific zygotic mRNAs encoding key mitotic, cytoskeletal, and nuclear proteins required to maintain nuclear viability.