N
Nehal A. Hamdy
Researcher at Cairo University
Publications - 29
Citations - 447
Nehal A. Hamdy is an academic researcher from Cairo University. The author has contributed to research in topics: Pyrazole & Benzimidazole. The author has an hindex of 11, co-authored 27 publications receiving 394 citations. Previous affiliations of Nehal A. Hamdy include Ain Shams University.
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Journal ArticleDOI
New pyridone, thioxopyridine, pyrazolopyridine and pyridine derivatives that modulate inflammatory mediators in stimulated RAW 264.7 murine macrophage.
TL;DR: The findings revealed that the derivatives 2b, 3b, 5a, 7b, 9a and 9b can be recognized as promising multi-potent anti-inflammatory agents in LPS-stimulated macrophages.
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Synthesis of some novel pyrazolo[1,5‐a]pyrimidine, 1,2,4‐triazolo[1,5‐a]pyrimidine, pyrido[2,3‐d]pyrimidine, pyrazolo[5,1‐c]‐1,2,4‐triazine and 1,2,4‐triazolo[5,1‐c]‐1,2,4‐triazine derivatives incorporating a thiazolo[3,2‐a]benzimidazole moiety
TL;DR: In this article, a mixture of 1-(3-methylthiazolo[3,2-a]benzimidazol-2-yl)ethanone with dimethylformamide-dimethylacetal was synthesized, which exhibited a moderate effect against some bacterial and fungal species.
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In vitro pharmacological and toxicological effects of norterpene peroxides isolated from the Red Sea sponge Diacarnus erythraeanus on normal and cancer cells.
Florence Lefranc,Genoveffa Nuzzo,Nehal A. Hamdy,Issa M. I. Fakhr,Laetitia Moreno Y Banuls,Gwendoline Van Goietsenoven,Guido Villani,Véronique Mathieu,Rob W. M. Van Soest,Robert Kiss,Maria Letizia Ciavatta +10 more
TL;DR: Eight cyclic peroxide norterpenoids, compounds 1-8, have been isolated and characterized from the Red Sea sponge Diacarnus erythraeanus, including two new norsesterterpene derivatives (3, 4), but compound 5 displayed no selectivity between normal and cancer cells in terms of in vitro growth inhibition.
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Immunomodulatory and anticancer activities of some novel 2-substituted-6-bromo-3-methylthiazolo[3,2-a]benzimidazole derivatives.
TL;DR: From the biological investigations compounds 9a and 9b were the most significant inhibitors of LPS‐stimulated NO generation from Raw murine macrophage 264, and, as another result, compounds 2 and 4 had a weak radical scavenging activity against DPPH radicals.
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Induction of intrinsic apoptosis pathway in colon cancer HCT-116 cells by novel 2-substituted-5,6,7,8-tetrahydronaphthalene derivatives.
Amira M. Gamal-Eldeen,Nehal A. Hamdy,Hatem A. Abdel-Aziz,Enas A. El-Hussieny,Issa M. I. Fakhr +4 more
TL;DR: Investigations of the cytotoxic effect of those compounds against different human cell lines indicated that some compounds showed high selective cytotoxicity against colon cancer HCT-116 cells and compounds 17b and 20b were promising anti-cancer agents that induced intrinsic apoptosis pathway in colon cancer cells.