Journal ArticleDOI
Synthesis of some novel pyrazolo[1,5‐a]pyrimidine, 1,2,4‐triazolo[1,5‐a]pyrimidine, pyrido[2,3‐d]pyrimidine, pyrazolo[5,1‐c]‐1,2,4‐triazine and 1,2,4‐triazolo[5,1‐c]‐1,2,4‐triazine derivatives incorporating a thiazolo[3,2‐a]benzimidazole moiety
TLDR
In this article, a mixture of 1-(3-methylthiazolo[3,2-a]benzimidazol-2-yl)ethanone with dimethylformamide-dimethylacetal was synthesized, which exhibited a moderate effect against some bacterial and fungal species.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2008-07-01. It has received 41 citations till now. The article focuses on the topics: Triazine & Pyrimidine.read more
Citations
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Microwave-assisted synthesis and in-vitro anti-tumor activity of 1,3,4-triaryl-5-N-arylpyrazole-carboxamides
TL;DR: Both the pyrazole-5-carboxamides and pyrazolylbenzimidazoles were examined for their in-vitro anti-tumor activities against two tumor cell lines, Hep-2 and colon CaCo-2.
Journal ArticleDOI
Facile Synthesis and In‐Vitro Antitumor Activity of Some Pyrazolo[3,4‐b]pyridines and Pyrazolo[1,5‐a]pyrimidines Linked to a Thiazolo[3,2‐a]benzimidazole Moiety
TL;DR: The synthesized compounds were tested for their in‐vitro antitumor activity against the colon cancer cell line CaCo‐2 and their cytotoxicity against the normal fibroblast cell line BHK; some of the tested compounds exhibited cell growth inhibitory activity.
Journal ArticleDOI
Thiazolo(3,2-a)benzimidazoles: Synthetic Strategies, Chemical Transformations and Biological Activities
TL;DR: The present review covers the recent synthetic strategies and chemical transformations of thiazolo[3,2-a]benzimidazoles and it also presents the highlights of the biological activities of these compounds.
Journal ArticleDOI
Tyrosine kinase inhibition effects of novel Pyrazolo[1,5-a]pyrimidines and Pyrido[2,3-d]pyrimidines ligand: Synthesis, biological screening and molecular modeling studies.
Mardia T. El Sayed,Hoda A. R. Hussein,Nora M. Elebiary,Ghada S. Hassan,Shahenda M. El-Messery,Ahmed R. El-Sheakh,Mohamed Nayel,Hatem A. Abdel-Aziz +7 more
TL;DR: Investigation of the novel Pyrazolo[1,5-a]pyrimidines and Pyrido[2,3-d]pyridines as a small molecules that can inhibit tyrosine kinase in cancer cells shows good agreement with the obtained biological results.
Journal ArticleDOI
Induction of intrinsic apoptosis pathway in colon cancer HCT-116 cells by novel 2-substituted-5,6,7,8-tetrahydronaphthalene derivatives.
Amira M. Gamal-Eldeen,Nehal A. Hamdy,Hatem A. Abdel-Aziz,Enas A. El-Hussieny,Issa M. I. Fakhr +4 more
TL;DR: Investigations of the cytotoxic effect of those compounds against different human cell lines indicated that some compounds showed high selective cytotoxicity against colon cancer HCT-116 cells and compounds 17b and 20b were promising anti-cancer agents that induced intrinsic apoptosis pathway in colon cancer cells.
References
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Journal ArticleDOI
5,6-Diaryl-2,3-dihydroimidazo[2,1-b]thiazoles: a new class of immunoregulatory antiinflammatory agents
Paul Elliot Bender,David T. Hill,P. H. Offen,K. A. Razgaitis,P. G. Lavanchy,Orum D. Stringer,Blaine M. Sutton,Don E. Griswold,Michael J. DiMartino,Donald T. Walz +9 more
TL;DR: A series of substituted 5,6-diaryl-2,3-dihydroimidazo[2,1-b]thiazoles were synthesized and evaluated in the rat adjuvant-induced arthritis and mouse oxazolone-induced contact sensitivity assays to determine the potential of these compounds for use as immunoregulatory antiinflammatory agents as discussed by the authors.
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Screening system for Egyptian plants with potential anti-tumour activity.
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Studies with enaminones: The reaction of enaminones with aminoheterocycles. A route to azolopyrimidines, azolopyridines and quinolines
TL;DR: The enaminones 1b,d,f react with 4-phenyl-3-methyl-5-pyrazoleamine 3a to yield the pyrazole derivatives 4a-c that cyclised readily on reflux in pyridine solution in presence of hydrochloric acid as mentioned in this paper.
Journal ArticleDOI
Derivatives of 3-Methylthiazolo[3,2-a]benzimidazole1,2
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Synthesis and Reactions of 3‐Methylthiazolo[3,2‐a]Benzimidazole‐2‐Carboxylic Acid Hydrazide: Synthesis of Some New Pyrazole, 1,3‐Thiazoline, 1,2,4‐Triazole and 1,2,4‐Triazolo[3,4‐b]‐1,3,4‐Thiadiazine Derivatives Pendant to Thiazolo[3,2‐a]Benzimidazole Moiety
TL;DR: In this article, the reaction of 3-methylthiazolo[3,2-a]benzimidazole-2-carboxylic acid ethyl ester with hydrazine hydrate gives the hydrazide 2 which reacts with CS 2 /KOH to afford the potassium salt 3.