N
Neil J. Hardegen
Researcher at National Institutes of Health
Publications - 7
Citations - 5221
Neil J. Hardegen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Protein subunit & U937 cell. The author has an hindex of 5, co-authored 7 publications receiving 4943 citations.
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Journal ArticleDOI
Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3
Wanjun Chen,Wenwen Jin,Neil J. Hardegen,Ke Jian Lei,Li Li,Nancy J. Marinos,George McGrady,Sharon M. Wahl +7 more
TL;DR: Novel evidence is presented that conversion of naive peripheral CD4+CD25− T cells into anergic/suppressor cells that are CD25+, CD45RB−/low and intracellular CTLA-4+ can be achieved through costimulation with T cell receptors (TCRs) and transforming growth factor β (TGF-β).
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Curcumin (diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-κB activation
TL;DR: The results demonstrate that the antiinflammatory properties of curcumin may be attributable, in part, to inhibition of leukocyte recruitment.
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Secretory Leukocyte Protease Inhibitor Binds to Annexin II, a Cofactor for Macrophage HIV-1 Infection
Ge Ma,Teresa Greenwell-Wild,Ke-Jian Lei,Wenwen Jin,Jennifer Swisher,Neil J. Hardegen,Carl T. Wild,Sharon M. Wahl +7 more
TL;DR: In this paper, the authors demonstrate that secretory leukocyte protease inhibitor (SLPI) binds to the membrane of human macrophages through the phospholipid-binding protein, annexin II.
Journal ArticleDOI
Mechanisms for macrophage-mediated HIV-1 induction.
Krishnakumar Devadas,Neil J. Hardegen,Larry M. Wahl,Indira Hewlett,Kathleen A. Clouse,Kenneth M. Yamada,Subhash Dhawan +6 more
TL;DR: Evidence is presented that activation of HIV-1 replication in latently infected U1 or ACH2 cells by human macrophages is mediated by a rapid nuclear localization of NF-κB p50/p65 dimer with concomitant increased expression of proinflammatory cytokines.
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Expression of Green Fluorescent Protein in Streptococcus gordonii DL1 and Its Use as a Species-Specific Marker in Coadhesion with Streptococcus oralis 34 in Saliva-Conditioned Biofilms In Vitro
Marcelo B. Aspiras,Karen Kazmerzak,Paul E. Kolenbrander,Roderick McNab,Neil J. Hardegen,Howard F. Jenkinson +5 more
TL;DR: Results show for the first time that GFP expression in oral streptococci can be used as a species-specific marker in model oral biofilms and study the spatial organization of S. gordonii DL1 in oral biofilm flowcell system.