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Bryan E. Thacker
Researcher at General Atomics
Publications - 23
Citations - 1837
Bryan E. Thacker is an academic researcher from General Atomics. The author has contributed to research in topics: Heparan sulfate & Heparin. The author has an hindex of 11, co-authored 18 publications receiving 1188 citations. Previous affiliations of Bryan E. Thacker include United States Department of Veterans Affairs & University of California, San Diego.
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Journal ArticleDOI
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.
Thomas Mandel Clausen,Thomas Mandel Clausen,Thomas Mandel Clausen,Daniel R. Sandoval,Charlotte B Spliid,Charlotte B Spliid,Charlotte B Spliid,Jessica Pihl,Jessica Pihl,Jessica Pihl,Hailee R. Perrett,Chelsea D. Painter,Anoop Narayanan,Sydney A. Majowicz,Elizabeth M. Kwong,Rachael N. McVicar,Bryan E. Thacker,Charles A. Glass,Zhang Yang,Jonathan L. Torres,Gregory J. Golden,Phillip L. Bartels,Ryan N. Porell,Aaron F. Garretson,Logan K. Laubach,Jared Feldman,Xin Yin,Yuan Pu,Blake M. Hauser,Timothy M. Caradonna,Benjamin P. Kellman,Cameron Martino,Philip L.S.M. Gordts,Sumit K. Chanda,Aaron G. Schmidt,Aaron G. Schmidt,Kamil Godula,Sandra L Leibel,Joyce Jose,Kevin D. Corbett,Andrew B. Ward,Aaron F. Carlin,Jeffrey D. Esko +42 more
TL;DR: A model in which viral attachment and infection involves heparan sulfate-dependent enhancement of binding to ACE2 is suggested, in which Manipulation of hepara sulfate or inhibition of viral adhesion by exogenous heparin presents new therapeutic opportunities.
Posted ContentDOI
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
Thomas Mandel Clausen,Daniel R. Sandoval,Charlotte B Spliid,Jessica Pihl,Hailee R. Perrett,Chelsea D. Painter,Anoop Narayanan,Sydney A. Majowicz,E. M. Kwong,Rachael N. McVicar,Bryan E. Thacker,Charles A. Glass,Zhang Yang,Jonathan L. Torres,Gregory J. Golden,Phillip L. Bartels,Ryan N. Porell,Aaron F. Garretson,Logan K. Laubach,Jared Feldman,Xin Yin,Yuan Pu,Blake M. Hauser,Timothy M. Caradonna,Benjamin P. Kellman,Cameron Martino,Gordts, Plsm, Chanda, S. K.,Aaron G. Schmidt,Kamil Godula,Sandra L Leibel,Joyce Jose,Kevin D. Corbett,Andrew B. Ward,Aaron F. Carlin,Jeffrey D. Esko +34 more
TL;DR: It is shown that SARS-CoV-2 spike protein interacts with cell surface heparan sulfate and angiotensin converting enzyme 2 (ACE2) through its Receptor Binding Domain and may represent new therapeutic opportunities for exogenous heparin.
Journal ArticleDOI
ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors
Philip L.S.M. Gordts,Ryan Nock,Ni-Huiping Son,Bastian Ramms,Irene Lew,Jon C. Gonzales,Bryan E. Thacker,Debapriya Basu,Richard G. Lee,Adam E. Mullick,Mark J. Graham,Ira J. Goldberg,Rosanne M. Crooke,Joseph L. Witztum,Jeffrey D. Esko +14 more
TL;DR: The data indicate that ApoC-III inhibits turnover of TG-rich lipoproteins primarily through a hepatic clearance mechanism mediated by the LDLR/LRP1 axis.
Journal ArticleDOI
Heparan Sulfate 3-O-sulfation: A Rare Modification in Search of a Function
TL;DR: This review describes the current understanding of the prevalence and structure of 3-O-sulfation sites, expression and substrate specificity of the 3-Sulfotransferase family and the emerging roles of 3 O-s sulfuration in biology.
Journal ArticleDOI
Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome
Madeline A. Lancaster,Dipika Gopal,Joon Kim,Sahar N. Saleem,Jennifer L. Silhavy,Carrie M. Louie,Bryan E. Thacker,Yuko Williams,Maha S. Zaki,Joseph G. Gleeson +9 more
TL;DR: These findings implicate a defect in Wnt signaling in the cerebellar midline phenotype seen in Joubert syndrome that can be overcome with Wnt stimulation.