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Niamh Foley
Researcher at Trinity College, Dublin
Publications - 4
Citations - 2887
Niamh Foley is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Innate immune system & Inflammation. The author has an hindex of 4, co-authored 4 publications receiving 2213 citations.
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Journal ArticleDOI
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill,Anne M. Curtis,Juraj Adamik,Eva M. Palsson-McDermott,Anne F. McGettrick,Gautam Goel,Christian Frezza,Nicholas J. Bernard,Beth Kelly,Niamh Foley,Liang Zheng,A. Gardet,Zhen Tong,S. S. Jany,Sinéad C. Corr,Moritz Haneklaus,Brian E. Caffrey,Kerry A. Pierce,Sarah R. Walmsley,F. C. Beasley,Eoin P. Cummins,Victor Nizet,Moira K. B. Whyte,Cormac T. Taylor,Hening Lin,Seth L. Masters,Eyal Gottlieb,Vincent P. Kelly,Clary B. Clish,Philip E. Auron,Ramnik J. Xavier,Ramnik J. Xavier,Luke A. J. O'Neill +32 more
TL;DR: The authors showed that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but not tumour-necrosis factor-α in mouse macrophages.
Journal ArticleDOI
Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1
Anne M. Curtis,Caio T. Fagundes,Guangrui Yang,Eva M. Palsson-McDermott,Paulina Wochal,Anne F. McGettrick,Niamh Foley,James O. Early,Lihong Chen,Hanrui Zhang,Chenyi Xue,Sarah S. Geiger,Karsten Hokamp,Muredach P. Reilly,Andrew N. Coogan,Elena Vigorito,Garret A. FitzGerald,Luke A. J. O'Neill +17 more
TL;DR: The clock in myeloid cells plays a role in LPS-induced sepsis by altering NF-κB activity and the induction of the microRNA miR-155, which leads to an innate immune response that is variably responsive to challenges across the circadian day.
Journal ArticleDOI
miR-107: a Toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes
Niamh Foley,Luke A. J. O'Neill +1 more
TL;DR: A possible link between the molecular phenomena of obesity and inflammation and the role that miR‐107 may contribute to these processes is discussed, including an attempt to limit insulin resistance, a feature of obesity‐related inflammation.
Journal ArticleDOI
The impact of childhood obesity on inflammation, innate immune cell frequency, and metabolic microRNA expression.
Eirin Carolan,Andrew E. Hogan,Michelle Corrigan,Gadintshware Gaotswe,Jean O'Connell,Niamh Foley,Luke A. J. O'Neill,Declan Cody,Donal O'Shea +8 more
TL;DR: Childhood obesity is associated with changes in immune cell frequency, inflammatory environment, and regulation of metabolic gene expression that are causally linked to the onset of metabolic disease in adulthood and suggest the future trajectory of obese children to the development of type 2 diabetes mellitus and premature cardiovascular disease.