S
Sinéad C. Corr
Researcher at Trinity College, Dublin
Publications - 37
Citations - 6408
Sinéad C. Corr is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Innate immune system & Medicine. The author has an hindex of 22, co-authored 31 publications receiving 4935 citations. Previous affiliations of Sinéad C. Corr include Monash Institute of Medical Research & University College Cork.
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Journal ArticleDOI
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill,Anne M. Curtis,Juraj Adamik,Eva M. Palsson-McDermott,Anne F. McGettrick,Gautam Goel,Christian Frezza,Nicholas J. Bernard,Beth Kelly,Niamh Foley,Liang Zheng,A. Gardet,Zhen Tong,S. S. Jany,Sinéad C. Corr,Moritz Haneklaus,Brian E. Caffrey,Kerry A. Pierce,Sarah R. Walmsley,F. C. Beasley,Eoin P. Cummins,Victor Nizet,Moira K. B. Whyte,Cormac T. Taylor,Hening Lin,Seth L. Masters,Eyal Gottlieb,Vincent P. Kelly,Clary B. Clish,Philip E. Auron,Ramnik J. Xavier,Ramnik J. Xavier,Luke A. J. O'Neill +32 more
TL;DR: The authors showed that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but not tumour-necrosis factor-α in mouse macrophages.
Journal ArticleDOI
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
Evanna L. Mills,Beth Kelly,Angela Logan,Ana S. H. Costa,Mukund Varma,Clare E. Bryant,Panagiotis Tourlomousis,J. Henry M. Däbritz,Eyal Gottlieb,Isabel J. Latorre,Sinéad C. Corr,Gavin J. McManus,Dylan G. Ryan,Howard T. Jacobs,Howard T. Jacobs,Marten Szibor,Marten Szibor,Marten Szibor,Ramnik J. Xavier,Thomas Braun,Christian Frezza,Michael P. Murphy,Luke A. J. O'Neill +22 more
TL;DR: It is demonstrated that upon lipopolysaccharide stimulation, macrophages shift from producing ATP by oxidative phosphorylation to glycolysis while also increasing succinate levels, and repurpose mitochondria from ATP synthesis to ROS production in order to promote a pro-inflammatory state.
Journal ArticleDOI
Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118
TL;DR: It is demonstrated that Lactobacillus salivarius UCC118, a recently sequenced and genetically tractable probiotic strain of human origin, produces a bacteriocin in vivo that can significantly protect mice against infection with the invasive foodborne pathogen Listeria monocytogenes.
Journal ArticleDOI
M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis
TL;DR: Understanding the mechanism by which M-cells sample antigen will inform the design of oral vaccines with improved efficacy in priming mucosal and systemic immune responses, and their role in mucosal immunity and pathogenesis of infections are discussed.
Journal ArticleDOI
A miR-19 regulon that controls NF-κB signaling
Michael P. Gantier,H. James Stunden,Claire E. McCoy,Mark A. Behlke,Die Wang,Maria Kaparakis-Liaskos,Soroush T. Sarvestani,Yuan Hang Yang,Dakang Xu,Sinéad C. Corr,Eric F Morand,Bryan R.G. Williams +11 more
TL;DR: This study constitutes, to the authors' knowledge, the first description of a miR-19 regulon that controls NF-κB signaling, and suggests that targeting this miRNA and linked family members could regulate the activity of NF- ΚB signaling in inflammation.