Z
Zhen Tong
Researcher at Howard Hughes Medical Institute
Publications - 7
Citations - 2965
Zhen Tong is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Chromatin & Histone H3. The author has an hindex of 7, co-authored 7 publications receiving 2199 citations. Previous affiliations of Zhen Tong include Cornell University & Tsinghua University.
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Journal ArticleDOI
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill,Anne M. Curtis,Juraj Adamik,Eva M. Palsson-McDermott,Anne F. McGettrick,Gautam Goel,Christian Frezza,Nicholas J. Bernard,Beth Kelly,Niamh Foley,Liang Zheng,A. Gardet,Zhen Tong,S. S. Jany,Sinéad C. Corr,Moritz Haneklaus,Brian E. Caffrey,Kerry A. Pierce,Sarah R. Walmsley,F. C. Beasley,Eoin P. Cummins,Victor Nizet,Moira K. B. Whyte,Cormac T. Taylor,Hening Lin,Seth L. Masters,Eyal Gottlieb,Vincent P. Kelly,Clary B. Clish,Philip E. Auron,Ramnik J. Xavier,Ramnik J. Xavier,Luke A. J. O'Neill +32 more
TL;DR: The authors showed that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but not tumour-necrosis factor-α in mouse macrophages.
Journal ArticleDOI
Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies.
TL;DR: This work provides a comprehensive review of protein lipidation, including descriptions of proteins known to be modified and the functions of the modifications, the enzymes that control them, and the tools and technologies developed to study them.
Journal ArticleDOI
SIRT7 Is an RNA-Activated Protein Lysine Deacylase
Zhen Tong,Miao Wang,Yi Wang,David D. Kim,Jennifer K. Grenier,Ji Cao,Sushabhan Sadhukhan,Quan Hao,Hening Lin +8 more
TL;DR: It is shown that RNA can increase the catalytic efficiency of SIRT7 even better and that Sirt7 can remove long chain fatty acyl groups more efficiently than removing acetyl groups.
Journal ArticleDOI
SIRT7 Is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context.
TL;DR: It is reported that SIRT7 can be activated by DNA to hydrolyze the acetyl group from lysine residues in vitro on histone peptides and histones in the chromatin context.
Journal ArticleDOI
Transmembrane Protein 198 Promotes LRP6 Phosphorylation and Wnt Signaling Activation
Juan Liang,Yu Fu,Cristina-Maria Cruciat,Shunji Jia,Ying Wang,Zhen Tong,Qinghua Tao,Dierk Ingelfinger,Michael Boutros,Anming Meng,Christof Niehrs,Wei Wu +11 more
TL;DR: TMEM198 is identified as a membrane scaffold protein that promotes LRP6 phosphorylation and Wnt signaling activation and is required for Wnt-mediated neural crest formation, antero-posterior patterning, and particularly engrailed-2 expression in Xenopus embryos.