N
Nicholas Lepak
Researcher at United States Department of Agriculture
Publications - 11
Citations - 2040
Nicholas Lepak is an academic researcher from United States Department of Agriculture. The author has contributed to research in topics: Population & Nested association mapping. The author has an hindex of 8, co-authored 10 publications receiving 1786 citations. Previous affiliations of Nicholas Lepak include Cornell University & Agricultural Research Service.
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Journal ArticleDOI
The Genetic Architecture of Maize Flowering Time
Edward S. Buckler,Edward S. Buckler,James B. Holland,James B. Holland,Peter J. Bradbury,Peter J. Bradbury,Charlotte B. Acharya,Patrick J. Brown,C. A. Browne,C. A. Browne,Elhan S. Ersoz,Sherry Flint-Garcia,Sherry Flint-Garcia,Arturo Garcia,Arturo Garcia,Jeffrey C. Glaubitz,Major M. Goodman,Carlos Harjes,Kate E. Guill,Kate E. Guill,Dallas E. Kroon,Sara Larsson,Nicholas Lepak,Nicholas Lepak,Huihui Li,Huihui Li,Sharon E. Mitchell,Gaël Pressoir,Jason A. Peiffer,Marco Oropeza Rosas,Torbert Rocheford,Torbert Rocheford,M. Cinta Romay,M. Cinta Romay,Susan Romero,Stella Salvo,Stella Salvo,Hector Sanchez Villeda,Hector Sanchez Villeda,H. Sofia da Silva,Qi Sun,Feng Tian,N. Upadyayula,Doreen Ware,Doreen Ware,Heather Yates,Jianming Yu,Zhiwu Zhang,Stephen Kresovich,Michael D. McMullen,Michael D. McMullen +50 more
TL;DR: A simple additive model accurately predicts flowering time for maize, in contrast to the genetic architecture observed in the selfing plant species rice and Arabidopsis.
Journal ArticleDOI
Dysregulation of expression correlates with rare-allele burden and fitness loss in maize.
Karl A. Kremling,Shu-Yun Chen,Mei-Hsiu Su,Nicholas Lepak,M. Cinta Romay,Kelly Swarts,Kelly Swarts,Fei Lu,Fei Lu,Anne Lorant,Peter J. Bradbury,Edward S. Buckler +11 more
TL;DR: A multi-tissue gene expression resource that represents the genotypic and phenotypic diversity of modern inbred maize is reported, and includes transcriptomes in an average of 255 lines in seven tissues, which suggests that historic bottlenecks have shaped regulation.
Journal ArticleDOI
Genomic estimation of complex traits reveals ancient maize adaptation to temperate North America
Kelly Swarts,Kelly Swarts,Rafal M. Gutaker,Bruce F. Benz,Michael Blake,Robert Bukowski,James B. Holland,Melissa Kruse-Peeples,Nicholas Lepak,Lynda Prim,M. Cinta Romay,Jeffrey Ross-Ibarra,José de Jesús Sánchez-González,Chris A. Schmidt,Verena J. Schuenemann,Johannes Krause,Johannes Krause,R. G. Matson,Detlef Weigel,Edward S. Buckler,Hernán A. Burbano +20 more
TL;DR: Indirectly validated genomic models predicted that Turkey Pen maize was marginally adapted with respect to flowering, as well as short, tillering, and segregating for yellow kernel color, a characteristic of modern temperate maize.
Journal ArticleDOI
The relationship between parental genetic or phenotypic divergence and progeny variation in the maize nested association mapping population
H-Y Hung,C. A. Browne,Katherine E. Guill,Nathan David Coles,Magen S. Eller,Arturo Garcia,Nicholas Lepak,S Melia-Hancock,Marco A. Oropeza-Rosas,S Salvo,N. Upadyayula,Edward S. Buckler,Sherry Flint-Garcia,Sherry Flint-Garcia,Michael D. McMullen,Michael D. McMullen,Torbert Rocheford,Torbert Rocheford,James B. Holland,James B. Holland +19 more
TL;DR: The choice of promising segregating populations can be based on selecting phenotypically diverse parents, congruent with models of genetic architecture that posit numerous genes affecting quantitative traits, each segregating for allelic series with dispersal of allelic effects across diverse genetic material.
Journal ArticleDOI
Genome-wide association of carbon and nitrogen metabolism in the maize nested association mapping population
Nengyi Zhang,Yves Gibon,Jason G. Wallace,Nicholas Lepak,Pinghua Li,Lauren K. Dedow,Charles Chen,Yoon-Sup So,Karl A. Kremling,Peter J. Bradbury,Thomas P. Brutnell,Thomas P. Brutnell,Mark Stitt,Edward S. Buckler +13 more
TL;DR: The integration of field-derived metabolite data with powerful mapping and genomics resources allows for the dissection of key metabolic pathways, providing avenues for future genetic improvement.