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Nicholas Locantore
Researcher at GlaxoSmithKline
Publications - 71
Citations - 7737
Nicholas Locantore is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: COPD & Exacerbation. The author has an hindex of 30, co-authored 71 publications receiving 6615 citations. Previous affiliations of Nicholas Locantore include RAND Corporation & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Susceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease
John R. Hurst,Jørgen Vestbo,Jørgen Vestbo,Antonio Anzueto,Nicholas Locantore,Hana Müllerová,Ruth Tal-Singer,Bruce E. Miller,David A. Lomas,Alvar Agusti,William MacNee,Peter M.A. Calverley,Stephen I. Rennard,Emiel F.M. Wouters,Jadwiga A. Wedzicha +14 more
TL;DR: Although exacerbations become more frequent and more severe as COPD progresses, the rate at which they occur appears to reflect an independent susceptibility phenotype, which has implications for the targeting of exacerbation-prevention strategies across the spectrum of disease severity.
Journal ArticleDOI
Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials
Steven Pascoe,Nicholas Locantore,Mark T. Dransfield,Mark T. Dransfield,Neil Barnes,Neil Barnes,Ian D. Pavord +6 more
TL;DR: Blood eosinophil count is a promising biomarker of response to inhaled corticosteroids in patients with COPD and could potentially be used to stratify patients for different exacerbation rate reduction strategies.
Journal ArticleDOI
Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease.
Bartolome R. Celli,Nicholas Locantore,Julie C. Yates,Ruth Tal-Singer,Bruce E. Miller,Per Bakke,Peter M.A. Calverley,Harvey O. Coxson,Courtney Crim,Lisa D. Edwards,David A. Lomas,Annelyse Duvoix,William MacNee,Stephen I. Rennard,Edwin K. Silverman,Jørgen Vestbo,Jørgen Vestbo,Emiel F.M. Wouters,Alvar Agusti +18 more
TL;DR: The addition of a panel of selected biomarkers improves the ability of established clinical variables to predict mortality in chronic obstructive pulmonary disease.
Journal ArticleDOI
Robust principal component analysis for functional data
Nicholas Locantore,James Stephen Marron,Douglas G. Simpson,N. Tripoli,Jin-Ting Zhang,K. L. Cohen,Graciela Boente,Ricardo Fraiman,Babette Brumback,Christophe Croux,Jianqing Fan,Alois Kneip,John I. Marden,Daniel Peña,Javier Prieto,James O. Ramsay,Mariano J. Valderrama,Ana M. Aguilera +17 more
TL;DR: A method for exploring the structure of populations of complex objects, such as images, is considered, and endemic outliers motivate the development of a bounded influence approach to PCA.
Journal ArticleDOI
Eosinophilic inflammation in COPD: prevalence and clinical characteristics
Dave Singh,Umme Kolsum,Christopher E. Brightling,Nicholas Locantore,Alvar Agusti,Ruth Tal-Singer +5 more
TL;DR: Observations suggest that eosinophilic airway inflammation in COPD is a predictive biomarker of corticosteroid responsiveness during clinical stability and exacerbations.