N
Nicholas M. Tran
Researcher at Harvard University
Publications - 23
Citations - 1947
Nicholas M. Tran is an academic researcher from Harvard University. The author has contributed to research in topics: Axon & Retina. The author has an hindex of 11, co-authored 19 publications receiving 1344 citations. Previous affiliations of Nicholas M. Tran include Washington University in St. Louis.
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Journal ArticleDOI
Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics.
Karthik Shekhar,Sylvain W. Lapan,Sylvain W. Lapan,Irene E. Whitney,Nicholas M. Tran,Evan Z. Macosko,Evan Z. Macosko,Monika S. Kowalczyk,Xian Adiconis,Joshua Z. Levin,James Nemesh,James Nemesh,Melissa Goldman,Melissa Goldman,Steven A. McCarroll,Steven A. McCarroll,Constance L. Cepko,Constance L. Cepko,Aviv Regev,Aviv Regev,Aviv Regev,Joshua R. Sanes +21 more
TL;DR: This work provides a systematic methodology for achieving comprehensive molecular classification of neurons, identifies novel neuronal types, and uncovers transcriptional differences that distinguish types within a class.
Journal ArticleDOI
Single-Cell Profiles of Retinal Ganglion Cells Differing in Resilience to Injury Reveal Neuroprotective Genes.
Nicholas M. Tran,Karthik Shekhar,Irene E. Whitney,Anne Jacobi,Inbal Benhar,Guosong Hong,Guosong Hong,Wenjun Yan,Xian Adiconis,McKinzie E. Arnold,Jung Min Lee,Joshua Z. Levin,Dingchang Lin,Chen Wang,Charles M. Lieber,Aviv Regev,Aviv Regev,Zhigang He,Joshua R. Sanes +18 more
TL;DR: It is shown that manipulating some of these genes improved neuronal survival and axon regeneration following ONC and demonstrates that differential gene expression can be used to reveal molecular targets for intervention.
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Mouse Retinal Cell Atlas: Molecular Identification of over Sixty Amacrine Cell Types.
Wenjun Yan,Mallory A. Laboulaye,Nicholas M. Tran,Irene E. Whitney,Inbal Benhar,Joshua R. Sanes +5 more
TL;DR: It is proposed that the mouse retina contains ∼130 neuronal types and is therefore comparable in complexity to other regions of the brain and provides evidence for the use of multiple neurotransmitters and neuropeptides.
Journal ArticleDOI
Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others.
Michael W. Norsworthy,Fengfeng Bei,Fengfeng Bei,Riki Kawaguchi,Q. Wang,Nicholas M. Tran,Yi Li,Benedikt Brommer,Yiming Zhang,Chen Wang,Joshua R. Sanes,Giovanni Coppola,Zhigang He +12 more
TL;DR: It is concluded that Sox11 can reprogram adult RGCs to a growth-competent state, suggesting that different growth-promoting interventions promote regeneration in distinct neuronal types.
Journal ArticleDOI
Satb1 Regulates Contactin 5 to Pattern Dendrites of a Mammalian Retinal Ganglion Cell.
Yi-Rong Peng,Nicholas M. Tran,Arjun Krishnaswamy,Dimitar Kostadinov,Emily M. Martersteck,Joshua R. Sanes +5 more
TL;DR: It is found that the transcriptional regulator Satb1 is selectively expressed by ooDSGCs, and directing formation of a morphologically and functionally specialized compartment within a complex dendritic arbor leads to branch-specific homophilic interactions with interneurons.