H
Heather O'Leary
Researcher at Indiana University
Publications - 47
Citations - 2216
Heather O'Leary is an academic researcher from Indiana University. The author has contributed to research in topics: Progenitor cell & Haematopoiesis. The author has an hindex of 21, co-authored 44 publications receiving 1852 citations. Previous affiliations of Heather O'Leary include West Virginia University & University of Colorado Denver.
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Journal ArticleDOI
Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock.
Charlie Mantel,Heather O'Leary,Brahmananda R. Chitteti,Xinxin Huang,Scott Cooper,Giao Hangoc,Nickolay Brustovetsky,Edward F. Srour,Man Ryul Lee,Man Ryul Lee,Steve Messina-Graham,David M. Haas,Nadia Falah,Reuben Kapur,Louis M. Pelus,Nabeel Bardeesy,Julien Fitamant,Mircea Ivan,Kye Seong Kim,Hal E. Broxmeyer +19 more
TL;DR: In this article, the extraphysiologic oxygen shock/stress (EPHOSS) phenomenon was found to decrease the recovery of long-term repopulating HSCs and increase progenitor cells.
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Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B.
TL;DR: It is shown that CaMKII reversibly translocates to synaptic sites in response to brief stimuli, but its resident time at the synapse increases after longer stimulation, which reflects temporal patterns of synaptic stimulation and supports an initial reversible and Ca2+/CaM-dependent binding at the substrate-binding site.
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Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis
Hal E. Broxmeyer,Jonathan Hoggatt,Jonathan Hoggatt,Heather O'Leary,Charlie Mantel,Brahmananda R. Chitteti,Scott Cooper,Steven Messina-Graham,Giao Hangoc,Sherif S. Farag,Sara L. Rohrabaugh,Xuan Ou,Jennifer M. Speth,Louis M. Pelus,Edward F. Srour,Timothy B. Campbell,Timothy B. Campbell +16 more
TL;DR: Hematopoiesis in mice after radiation or chemotherapy was enhanced in Dpp4−/− mice or mice receiving an orally active DPP4 inhibitor, suggesting the potential clinical utility of this approach.
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Dual Mechanism of a Natural CaMKII Inhibitor
TL;DR: The inhibitory mechanism of CaM-KIIN is revealed and a powerful new tool for dissecting CaMKII function is established, as CN21 (derived from CaKIN amino acids 43-63) showed full specificity and potency of CaMK II inhibition.
Journal ArticleDOI
Autonomous CaMKII Mediates Both LTP and LTD Using a Mechanism for Differential Substrate Site Selection
Steven J. Coultrap,Ronald K. Freund,Heather O'Leary,Jennifer L. Sanderson,Katherine W. Roche,Mark L. Dell'Acqua,K. Ulrich Bayer +6 more
TL;DR: It is found that requirement of autonomous CaMKII in opposing forms of plasticity involves distinct substrate classes that are differentially regulated to enable stimulus-dependent substrate-site preference.