N
Nicola Crosetto
Researcher at Karolinska Institutet
Publications - 50
Citations - 3978
Nicola Crosetto is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 17, co-authored 35 publications receiving 3287 citations. Previous affiliations of Nicola Crosetto include Goethe University Frankfurt & Science for Life Laboratory.
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Journal ArticleDOI
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
Marzena Bienko,Catherine M. Green,Nicola Crosetto,Fabian Rudolf,Grzegorz Zapart,Barry Coull,Patricia Kannouche,Gerhard Wider,Matthias Peter,Alan R. Lehmann,Kay Hofmann,Ivan Dikic +11 more
TL;DR: In this article, the identification of two ubiquitin (Ub)-binding domains (UBM and UBZ), which are evolutionarily conserved in all Y-family TLS polymerases (pols), is described.
Journal ArticleDOI
Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing
Charissa Kim,Ruli Gao,Emi Sei,Rachel Brandt,Johan Hartman,Thomas Hatschek,Nicola Crosetto,Theodoros Foukakis,Nicholas Navin +8 more
TL;DR: The data showed that resistant genotypes were pre-existing and adaptively selected by NAC, while transcriptional profiles were acquired by reprogramming in response to chemotherapy in TNBC patients.
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Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing
Nicola Crosetto,Abhishek Mitra,Maria Joao Silva,Magda Bienko,Magda Bienko,Norbert Dojer,Norbert Dojer,Qi Wang,Qi Wang,Elif Karaca,Elif Karaca,Roberto Chiarle,Roberto Chiarle,Roberto Chiarle,Magdalena Skrzypczak,Krzysztof Ginalski,Philippe Pasero,Maga Rowicka,Ivan Dikic +18 more
TL;DR: The genomic landscape of sensitivity to replication stress in human cells was characterized, and >2,000 nonuniformly distributed aphidicolin-sensitive regions (ASRs) overrepresented in genes and enriched in satellite repeats were identified.
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Spatially resolved transcriptomics and beyond
TL;DR: Pioneering technologies that enable spatially resolved transcriptomics are summarized and how these methods have the potential to extend beyond transcriptomics to encompass spatially resolution genomics, proteomics and possibly other omic disciplines are discussed.
Journal ArticleDOI
Regulation of ubiquitin-binding proteins by monoubiquitination.
Daniela Hoeller,Nicola Crosetto,Blagoy Blagoev,Camilla Raiborg,Ritva Tikkanen,Sebastian Wagner,Katarzyna Kowanetz,Rainer Breitling,Matthias Mann,Harald Stenmark,Ivan Dikic +10 more
TL;DR: It is demonstrated that monoubiquitination of the endocytic proteins Sts1, Sts2, Eps15 and Hrs results in intramolecular interactions between ubiquitin and their UBDs, thereby preventing them from binding in trans to ubiquitinated targets.