Nicolas Simon

TL;DR: It is suggested that external evaluation should be the first step in a pharmacokinetic analysis of vancomycin rather than describing a new model, and a sensitive liquid chromatography-tandem mass spectrometry method could be used and new covariates such as cardiac output or possible renal transporters could be tested.

TL;DR: OLP is often used in cases of therapeutic dead-ends or for specific disorders with few or no currently approved medications, however, other OLP practices only reflect temporary prescription trends for mild symptoms, which may induce safety concerns.

TL;DR: VMF seemed safe and effective in children with refractory BRAFV600E-positive LCH and none of the various empirical therapies used for maintenance could eradicate the BRAFv600E clone.

TL;DR: The results show that AAG plasma concentrations are increased in these types of cancers and that changes in the expression of the genetic variants of AAG could also occur according to the type of cancer.

TL;DR: Diurnal variations of clinical, biologic, or experimental factors described with Parkinson's disease are reviewed to review diurnal changes of circadian rhythms in dopaminergic systems as well as possible daily fluctuations in kinetics of drug treatments.