F
Falk Kiefer
Researcher at Heidelberg University
Publications - 380
Citations - 11269
Falk Kiefer is an academic researcher from Heidelberg University. The author has contributed to research in topics: Alcohol dependence & Craving. The author has an hindex of 54, co-authored 344 publications receiving 9451 citations. Previous affiliations of Falk Kiefer include Ludwig Maximilian University of Munich & Eppendorf (Germany).
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Journal ArticleDOI
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Raymond K. Walters,Raymond K. Walters,Renato Polimanti,Emma C. Johnson,Jeanette N. McClintick,Mark Adams,Amy E. Adkins,Fazil Aliev,Silviu-Alin Bacanu,Anthony Batzler,Sarah Bertelsen,Joanna M. Biernacka,Tim B. Bigdeli,Li-Shiun Chen,Toni-Kim Clarke,Yi-Ling Chou,Franziska Degenhardt,Anna R. Docherty,Alexis C. Edwards,Pierre Fontanillas,Jerome C. Foo,Louis Fox,Josef Frank,Ina Giegling,Scott Gordon,Laura M. Hack,Annette M. Hartmann,Sarah M. Hartz,Stefanie Heilmann-Heimbach,Stefan Herms,Stefan Herms,Colin A. Hodgkinson,Per Hoffmann,Per Hoffmann,Jouke-Jan Hottenga,Martin A. Kennedy,Mervi Alanne-Kinnunen,Bettina Konte,Jari Lahti,Marius Lahti-Pulkkinen,Dongbing Lai,Lannie Ligthart,Anu Loukola,Brion S. Maher,Hamdi Mbarek,Andrew M. McIntosh,Matthew B. McQueen,Jacquelyn L. Meyers,Yuri Milaneschi,Teemu Palviainen,John F. Pearson,Roseann E. Peterson,Samuli Ripatti,Euijung Ryu,Nancy L. Saccone,Jessica E. Salvatore,Sandra Sanchez-Roige,Melanie L. Schwandt,Richard Sherva,Fabian Streit,Jana Strohmaier,Nathaniel Thomas,Jen-Chyong Wang,Bradley T. Webb,Robbee Wedow,Leah Wetherill,Amanda G. Wills,Jason D. Boardman,Danfeng Chen,Doo Sup Choi,William E. Copeland,Robert Culverhouse,Norbert Dahmen,Louisa Degenhardt,Benjamin W. Domingue,Sarah L. Elson,Mark A. Frye,Wolfgang Gäbel,Caroline Hayward,Marcus Ising,Margaret Keyes,Falk Kiefer,John Kramer,Samuel Kuperman,Susanne Lucae,Michael T. Lynskey,Wolfgang Maier,Karl Mann,Satu Männistö,Bertram Müller-Myhsok,Alison D. Murray,John I. Nurnberger,Aarno Palotie,Ulrich W. Preuss,Katri Räikkönen,Maureen Reynolds,Monika Ridinger,Norbert Scherbaum,Marc A. Schuckit,Michael Soyka,Michael Soyka,Jens Treutlein,Stephanie H. Witt,Norbert Wodarz,Peter Zill,Daniel E. Adkins,Joseph M. Boden,Dorret I. Boomsma,Laura J. Bierut,Sandra A. Brown,Kathleen K. Bucholz,Sven Cichon,E. Jane Costello,Harriet de Wit,Nancy Diazgranados,Danielle M. Dick,Johan G. Eriksson,Lindsay A. Farrer,Tatiana Foroud,Nathan A. Gillespie,Alison Goate,David Goldman,Richard A. Grucza,Dana B. Hancock,Kathleen Mullan Harris,Andrew C. Heath,Victor Hesselbrock,John K. Hewitt,Christian J. Hopfer,John Horwood,William G. Iacono,Eric O. Johnson,Jaakko Kaprio,Victor M. Karpyak,Kenneth S. Kendler,Henry R. Kranzler,Kenneth Krauter,Paul Lichtenstein,Penelope A. Lind,Matt McGue,James MacKillop,Pamela A. F. Madden,Hermine H. Maes,Patrik K. E. Magnusson,Nicholas G. Martin,Sarah E. Medland,Grant W. Montgomery,Elliot C. Nelson,Markus M. Nöthen,Abraham A. Palmer,Nancy L. Pedersen,Brenda W. J. H. Penninx,Bernice Porjesz,John P. Rice,Marcella Rietschel,Brien P. Riley,Richard J. Rose,Dan Rujescu,Pei-Hong Shen,Judy L. Silberg,Michael C. Stallings,Ralph E. Tarter,Michael M. Vanyukov,Scott I. Vrieze,Tamara L. Wall,John Whitfield,Hongyu Zhao,Benjamin M. Neale,Benjamin M. Neale,Joel Gelernter,Howard J. Edenberg,Arpana Agrawal +171 more
TL;DR: The largest genome-wide association study to date of DSM-IV-diagnosed AD found loci associated with AD and characterized the relationship between AD and other psychiatric and behavioral outcomes, underscoring the genetic distinction between pathological and nonpathological drinking behaviors.
Journal ArticleDOI
A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis
Stephan Buch,Felix Stickel,Eric Trepo,Michael J. Way,A Herrmann,Hans Dieter Nischalke,Mario Brosch,Jonas Rosendahl,Thomas Berg,Monika Ridinger,Marcella Rietschel,Andrew McQuillin,Josef Frank,Falk Kiefer,Stefan Schreiber,Wolfgang Lieb,Michael Soyka,Nasser Semmo,Elmar Aigner,Christian Datz,Renate Schmelz,Stefan Brückner,Sebastian Zeissig,Anna-Magdalena Stephan,Norbert Wodarz,Jacques Devière,Nicolas Clumeck,Christoph Sarrazin,Frank Lammert,Thierry Gustot,Pierre Deltenre,Pierre Deltenre,Henry Völzke,Markus M. Lerch,Julia Mayerle,Florian Eyer,Clemens Schafmayer,Sven Cichon,Markus M. Nöthen,Michael Nothnagel,David Ellinghaus,Klaus Huse,Andre Franke,Steffen Zopf,Claus Hellerbrand,Christophe Moreno,Denis Franchimont,Marsha Y. Morgan,Jochen Hampe +48 more
TL;DR: A genome-wide association study for alcohol-related cirrhosis in individuals of European descent with subsequent validation in two independent European cohorts is performed, suggesting that lipid turnover is important in the pathogenesis of alcohol- related Cirrhosis.
Journal ArticleDOI
Comparing and Combining Naltrexone and Acamprosate in Relapse Prevention of Alcoholism: A Double-blind, Placebo-Controlled Study
Falk Kiefer,Holger Jahn,Timo Tarnaske,Hauke Helwig,Peer Briken,Rüdiger Holzbach,Philipp Kämpf,Robert Stracke,Michael Baehr,Dieter Naber,Klaus Wiedemann +10 more
TL;DR: The results of this study support the efficacy of pharmacotherapeutic strategies in the relapse prevention of alcoholism as naltrexone and acamprosate considerably enhance the potential of relapse prevention.
Journal ArticleDOI
Genome-wide association study of alcohol dependence.
Jens Treutlein,Sven Cichon,Monika Ridinger,Norbert Wodarz,Michael Soyka,Peter Zill,Wolfgang Maier,Rainald Moessner,Wolfgang Gaebel,Norbert Dahmen,Christoph Fehr,Norbert Scherbaum,Michael Steffens,Kerstin U. Ludwig,Josef Frank,H.-Erich Wichmann,Stefan Schreiber,Nico Dragano,Wolfgang H. Sommer,Fernando Leonardi-Essmann,Anbarasu Lourdusamy,Peter J. Gebicke-Haerter,Thomas F. Wienker,Patrick F. Sullivan,Markus M. Nöthen,Falk Kiefer,Rainer Spanagel,Karl Mann,Marcella Rietschel +28 more
TL;DR: This is the first GWAS and follow-up study to identify a genome-wide significant association in alcohol dependence and nine SNPs were located in genes that have been reported to be associated with alcohol dependence, including the CDH13 and ADH1C genes.
Journal ArticleDOI
Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians
Felix Stickel,Stephan Buch,Katharina Lau,Henriette E. Meyer zu Schwabedissen,Thomas Berg,Monika Ridinger,Marcella Rietschel,Clemens Schafmayer,Felix Braun,Holger Hinrichsen,Rainer Günther,Alexander Arlt,Marcus Seeger,Sebastian Müller,Helmut K. Seitz,Michael Soyka,Markus M. Lerch,Frank Lammert,Christoph Sarrazin,Ralf Kubitz,Dieter Häussinger,C Hellerbrand,D Bröring,Stefan Schreiber,Falk Kiefer,Rainer Spanagel,Karl Mann,Christian Datz,Michael Krawczak,Norbert Wodarz,Henry Völzke,Jochen Hampe +31 more
TL;DR: Genotype PNPLA3 rs738409(GG) is associated with alcoholic liver cirrhosis and elevated aminotransferase levels in alcoholic Caucasians.