N
Nicole Traugh
Researcher at Harvard University
Publications - 12
Citations - 5831
Nicole Traugh is an academic researcher from Harvard University. The author has contributed to research in topics: Immunotherapy & Immune checkpoint. The author has an hindex of 5, co-authored 11 publications receiving 2088 citations.
Papers
More filters
Journal ArticleDOI
TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells
Taiwen Li,Taiwen Li,Jingyu Fan,Binbin Wang,Nicole Traugh,Qianming Chen,Jun Liu,Bo Li,X. Shirley Liu,X. Shirley Liu +9 more
TL;DR: Tumor Immune Estimation Resource (TIMER) is presented to comprehensively investigate molecular characterization of tumor-immune interactions and provides a user-friendly web interface for dynamic analysis and visualization of these associations, which will be of broad utilities to cancer researchers.
Journal ArticleDOI
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
Peng Jiang,Shengqing Gu,Deng Pan,Jingxin Fu,Avinash Das Sahu,Xihao Hu,Ziyi Li,Nicole Traugh,Xia Bu,Bo Li,Bo Li,Jun Liu,Gordon J. Freeman,Myles Brown,Kai W. Wucherpfennig,X. Shirley Liu +15 more
TL;DR: An algorithm-selected gene signature focused on tumor immune evasion and suppression predicts response to immune checkpoint blockade in melanoma, exceeding the accuracy of current clinical biomarkers.
Journal ArticleDOI
Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute.
Binbin Wang,Mei Wang,Wubing Zhang,Tengfei Xiao,Chen-Hao Chen,Alexander C. Wu,Feizhen Wu,Nicole Traugh,Xiaoqing Wang,Ziyi Li,Shenglin Mei,Yingbo Cui,Sailing Shi,Jesse J. Lipp,Matthias Hinterndorfer,Johannes Zuber,Myles Brown,Wei Li,Wei Li,X. Shirley Liu,X. Shirley Liu +20 more
TL;DR: This protocol explains how to use MAGeCKFlute to perform quality control (QC), normalization, batch effect removal, copy-number bias correction, gene hit identification and downstream functional enrichment analysis for CRISPR screens.
Journal ArticleDOI
Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade.
Shengqing Stan Gu,Wubing Zhang,Wubing Zhang,Xiaoqing Wang,Peng Jiang,Nicole Traugh,Ziyi Li,Ziyi Li,Clifford A. Meyer,Blair Stewig,Yingtian Xie,Xia Bu,Michael Manos,Alba Font-Tello,Evisa Gjini,Ana Lako,Klothilda Lim,Jake Conway,Alok K. Tewari,Zexian Zeng,Avinash Das Sahu,Collin Tokheim,Jason L. Weirather,Jingxin Fu,Jingxin Fu,Yi Zhang,Benjamin Kroger,Jin Hua Liang,Jin Hua Liang,Paloma Cejas,Gordon J. Freeman,Scott J. Rodig,Henry W. Long,Benjamin E. Gewurz,Benjamin E. Gewurz,F. Stephen Hodi,Myles Brown,X. Shirley Liu +37 more
TL;DR: In this article, the authors combined FACS-based genome-wide CRISPR screens with a data-mining approach to identify drugs that can upregulate MHC-I without inducing PD-L1.
Journal ArticleDOI
In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target
Xiaoqing Wang,Collin Tokheim,Shengqing Stan Gu,Binbin Wang,Qin Tang,Yihao Li,Nicole Traugh,Zexian Zeng,Yi Zhang,Ziyi Li,Boning Zhang,Jingxin Fu,Tengfei Xiao,Wei Li,Clifford A. Meyer,Jun Chu,Peng Jiang,Paloma Cejas,Klothilda Lim,Henry W. Long,Myles Brown,X. Shirley Liu +21 more
TL;DR: Collapsed in vivo CRISPR knockout screens identify new immune targets regulating the tumor microenvironment and implicates Cop1 as a target for improving cancer immunotherapy efficacy by regulating chemokine secretion and macrophage levels in the TNBC tumor micro environment.