N
Nicoletta Zini
Researcher at National Research Council
Publications - 145
Citations - 4866
Nicoletta Zini is an academic researcher from National Research Council. The author has contributed to research in topics: Mesenchymal stem cell & Nuclear matrix. The author has an hindex of 35, co-authored 141 publications receiving 4104 citations. Previous affiliations of Nicoletta Zini include Nuclear Regulatory Commission & University of Bologna.
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Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species.
Serena Rubina Baglìo,Koos Rooijers,Danijela Koppers-Lalic,Frederik J. Verweij,M Pérez Lanzón,Nicoletta Zini,B.A. Naaijkens,Francesca Perut,Hans W.M. Niessen,Nicola Baldini,D. Michiel Pegtel +10 more
TL;DR: It is demonstrated that primary MSCs release small RNAs via exosomes, which are increasingly implicated in intercellular communications, and may help to understand how M SCs impact neighboring or distant cells with possible consequences for their therapeutic usage.
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Nontemplated Nucleotide Additions Distinguish the Small RNA Composition in Cells from Exosomes
Danijela Koppers-Lalic,Michael Hackenberg,Irene V. Bijnsdorp,Monique A. J. van Eijndhoven,Payman Sadek,D. Sie,Nicoletta Zini,Jaap M. Middeldorp,Bauke Ylstra,Renee X. de Menezes,Thomas Wurdinger,Thomas Wurdinger,Gerrit A. Meijer,D. Michiel Pegtel +13 more
TL;DR: It is suggested that posttranscriptional modifications, notably 3' end adenylation and uridylation, exert opposing effects that may contribute, at least in part, to direct ncRNA sorting into EVs.
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Blocking tumor-educated MSC paracrine activity halts osteosarcoma progression
S. Rubina Baglio,Tonny Lagerweij,Maria Pérez-Lanzón,Xuan Dung Ho,Nicolas Léveillé,Sonia A. Melo,Anne-Marie Cleton-Jansen,Ekaterina S. Jordanova,Laura Roncuzzi,M. Greco,Monique A. J. van Eijndhoven,Giulia Grisendi,Massimo Dominici,Roberta Bonafede,Roberta Bonafede,Sinéad M. Lougheed,Tanja D. de Gruijl,Nicoletta Zini,Silvia Cervo,Agostino Steffan,Vincenzo Canzonieri,Aare Märtson,Aare Märtson,Katre Maasalu,Katre Maasalu,Sulev Kõks,Sulev Kõks,Thomas Wurdinger,Thomas Wurdinger,Nicola Baldini,D. Michiel Pegtel +30 more
TL;DR: It is suggested that TEMSCs promote osteosarcoma progression and provide the basis for testing IL6- and TGFβ-blocking agents as new therapeutic options for osteosARcoma patients.
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Exosomes: novel effectors of human platelet lysate activity
Elena Torreggiani,Francesca Perut,Laura Roncuzzi,Nicoletta Zini,Serena Rubina Baglìo,Nicola Baldini +5 more
TL;DR: It is suggested that exosomes consistently contribute to PL activity and could represent an advantageous nanodelivery system for cell-free regeneration therapies.
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Anti‐Fas–induced apoptosis in chondrocytes reduced by hyaluronan: Evidence for CD44 and CD54 (intercellular adhesion molecule 1) involvement
Gina Lisignoli,Francesco Grassi,Nicoletta Zini,S. Toneguzzi,Anna Piacentini,Diego Guidolin,Carla Bevilacqua,Andrea Facchini +7 more
TL;DR: These data demonstrate that 500-730-kd HA exerts an antiapoptotic effect on anti-FAS-induced chondrocyte apoptosis by binding its specific receptors (CD44 and ICAM-1), and this HA fraction may be able to slow down chondrospecific apoptosis in OA by regulating the processes of cartilage matrix degradation.