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Nicolò Musso
Researcher at University of Catania
Publications - 69
Citations - 1168
Nicolò Musso is an academic researcher from University of Catania. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 17, co-authored 53 publications receiving 726 citations. Previous affiliations of Nicolò Musso include Scuola superiore di Catania.
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Journal ArticleDOI
Sensitivity assessment of droplet digital PCR for SARS-CoV-2 detection.
Luca Falzone,Nicolò Musso,Giuseppe Gattuso,Dafne Bongiorno,Concetta Ilenia Palermo,Guido Scalia,Massimo Libra,Stefania Stefani +7 more
TL;DR: In this article, the authors evaluated the sensitivity of droplet digital PCR (ddPCR) and reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and concluded that ddPCR showed higher sensitivity and specificity compared to RT-q-PCR for the diagnosis of COVID-19 infection in false negative samples with low viral load.
Journal ArticleDOI
Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1
Giuseppe Caruso,Claudia G. Fresta,Nicolò Musso,Mariaconcetta Giambirtone,Margherita Grasso,Simona Federica Spampinato,Sara Merlo,Filippo Drago,Giuseppe Lazzarino,Maria Angela Sortino,Susan M. Lunte,Filippo Caraci +11 more
TL;DR: The data suggest a multimodal mechanism of action of carnosine underlying its protective effects on microglial cells against Aβ toxicity with a key role of TGF-β1 in mediating these protective effects.
Journal ArticleDOI
Modulation of Pro-Oxidant and Pro-Inflammatory Activities of M1 Macrophages by the Natural Dipeptide Carnosine
Claudia G. Fresta,Annamaria Fidilio,Giacomo Lazzarino,Nicolò Musso,Margherita Grasso,Sara Merlo,Angela Maria Amorini,Claudio Bucolo,Barbara Tavazzi,Giuseppe Lazzarino,Susan M. Lunte,Filippo Caraci,Giuseppe Caruso +12 more
TL;DR: The ability of carnosine to modulate pro-oxidant and pro-inflammatory activities of macrophages is reported, representing the primary cell type that is activated as a part of the immune response, and worth being tested in the treatment of diseases characterized by elevated levels of oxidative stress and inflammation.
Journal ArticleDOI
Transcriptome analysis of copper homeostasis genes reveals coordinated upregulation of SLC31A1, SCO1, and COX11 in colorectal cancer
Vincenza Barresi,Angela Trovato-Salinaro,Giorgia Spampinato,Nicolò Musso,Sergio Castorina,Enrico Rizzarelli,Daniele F. Condorelli +6 more
TL;DR: It is revealed that inactivating mutations are absent or extremely rare in CHGs, and transcriptional upregulation of SLC31A1, SCO1, and COX11 was confirmed by the analysis of different colon carcinoma cell lines.
Journal ArticleDOI
Fluoxetine and Vortioxetine Reverse Depressive-Like Phenotype and Memory Deficits Induced by Aβ1-42 Oligomers in Mice: A Key Role of Transforming Growth Factor-β1.
Sebastiano Alfio Torrisi,Federica Geraci,Maria Rosaria Tropea,Margherita Grasso,Giuseppe Caruso,Annamaria Fidilio,Nicolò Musso,Giulia Sanfilippo,Fabio Tascedda,Agostino Palmeri,Salvatore Salomone,Filippo Drago,Daniela Puzzo,Gian Marco Leggio,Filippo Caraci +14 more
TL;DR: This is the first evidence that a chronic treatment with fluoxetine or vortioxetine can prevent both cognitive deficits and depressive-like phenotype in a non-transgenic animal model of AD with a key contribution of TGF-β1.