Margherita Grasso

TL;DR: The results show that both functional and developmental alterations in the neuron may account for the severe impairment of learning abilities as a consequence of mutations in GDI1, emphasizing its critical role in development of human intellectual and learning abilities.

TL;DR: The data suggest a multimodal mechanism of action of carnosine underlying its protective effects on microglial cells against Aβ toxicity with a key role of TGF-β1 in mediating these protective effects.

TL;DR: The ability of carnosine to modulate pro-oxidant and pro-inflammatory activities of macrophages is reported, representing the primary cell type that is activated as a part of the immune response, and worth being tested in the treatment of diseases characterized by elevated levels of oxidative stress and inflammation.

TL;DR: This is the first evidence that a chronic treatment with fluoxetine or vortioxetine can prevent both cognitive deficits and depressive-like phenotype in a non-transgenic animal model of AD with a key contribution of TGF-β1.

TL;DR: A multimodal mechanism of action of carnosine is suggested underlying its beneficial effects on macrophage cells under oxidative stress and inflammation conditions, indicating a strong inhibitory effect of this molecule towards the main source of reactive oxygen species in macrophages.