Nicolò Musso

TL;DR: In this article, the authors evaluated the sensitivity of droplet digital PCR (ddPCR) and reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and concluded that ddPCR showed higher sensitivity and specificity compared to RT-q-PCR for the diagnosis of COVID-19 infection in false negative samples with low viral load.

TL;DR: The data suggest a multimodal mechanism of action of carnosine underlying its protective effects on microglial cells against Aβ toxicity with a key role of TGF-β1 in mediating these protective effects.

TL;DR: The ability of carnosine to modulate pro-oxidant and pro-inflammatory activities of macrophages is reported, representing the primary cell type that is activated as a part of the immune response, and worth being tested in the treatment of diseases characterized by elevated levels of oxidative stress and inflammation.

TL;DR: It is revealed that inactivating mutations are absent or extremely rare in CHGs, and transcriptional upregulation of SLC31A1, SCO1, and COX11 was confirmed by the analysis of different colon carcinoma cell lines.

TL;DR: This is the first evidence that a chronic treatment with fluoxetine or vortioxetine can prevent both cognitive deficits and depressive-like phenotype in a non-transgenic animal model of AD with a key contribution of TGF-β1.