Niklas Czeloth

TL;DR: The data identify CCR7 as a key regulator that governs trafficking of skin DC under both inflammatory and steady-state conditions and provides evidence that these cells represent a semimature population of DC that is capable of initiating T cell proliferation under conditions known to induce tolerance.

TL;DR: An essential role for CCR9 is revealed in the homing of pDC to the intestine under homeostatic and inflammatory conditions and an important role is demonstrated for intestinal pDC for the rapid mobilization of lamina propria DC is demonstrated.

TL;DR: Sphingosine-1-phosphate-mediated signaling plays a pivotal role in the life cycle of DC, and a similar block was observed upon preventing Cdc42/Rac and/or Rho activation by specific inhibitors.

TL;DR: It is suggested that therapeutic approaches to treat GVHD should rely on nTreg, whereas the use of de novo alloantigen‐induced iTreg should be handled with caution since the stability of the regulatory phenotype of the iTreg could be of major concern.

TL;DR: Oral administered antigen evoked less efficient IgG and IgA antibody responses despite of normal IgM titers when compared to wild‐type mice, suggesting CD155 may assist in an efficient humoral immune response generated within the intestinal immune system.