CCR7 Governs Skin Dendritic Cell Migration under Inflammatory and Steady-State Conditions
Lars Ohl,Mariette Mohaupt,Niklas Czeloth,Gabriele Hintzen,Ziba Kiafard,Jörg Zwirner,Thomas Blankenstein,Golo Henning,Reinhold Förster +8 more
TLDR
The data identify CCR7 as a key regulator that governs trafficking of skin DC under both inflammatory and steady-state conditions and provides evidence that these cells represent a semimature population of DC that is capable of initiating T cell proliferation under conditions known to induce tolerance.About:
This article is published in Immunity.The article was published on 2004-08-01 and is currently open access. It has received 980 citations till now. The article focuses on the topics: Dendritic cell migration & CC chemokine receptors.read more
Citations
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Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
TL;DR: Results of older bio-kinetic studies with NSPs and newer epidemiologic and toxicologic studies with airborne ultrafine particles can be viewed as the basis for the expanding field of nanotoxicology, which can be defined as safety evaluation of engineered nanostructures and nanodevices.
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The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting.
TL;DR: This review discusses major advances in the understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.
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Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
Emmanuel L. Gautier,Tal Shay,Tal Shay,Jennifer Miller,Melanie Greter,Claudia Jakubzick,Stoyan Ivanov,Julie Helft,Andrew Chow,Kutlu G. Elpek,Simon Gordonov,Amin R. Mazloom,Avi Ma'ayan,Wei-Jen Chua,Ted H. Hansen,Shannon J. Turley,Miriam Merad,Gwendalyn J. Randolph +17 more
TL;DR: It is identified how well-characterized surface markers, including MerTK and FcγR1 (CD64), along with a cluster of previously unidentified transcripts, were distinctly and universally associated with mature tissue macrophages and how these transcripts and the proteins they encode facilitated distinguishing macrophage from dendritic cells.
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Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity
TL;DR: This review focuses on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.
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Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces
Yuri P. Rubtsov,Jeffrey P. Rasmussen,Emil Y. Chi,Jason D. Fontenot,Luca Castelli,Xin Ye,Piper M. Treuting,Lisa Siewe,Axel Roers,William R. Henderson,Werner Müller,Alexander Y. Rudensky +11 more
TL;DR: This study suggests that Treg cells utilize multiple means to limit immune responses, and these mechanisms are likely to be nonredundant, in that a distinct suppressor mechanism most likely plays a prominent and identifiable role at a particular tissue and inflammatory setting.
References
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The dendritic cell system and its role in immunogenicity
TL;DR: Dendritic cells are specialized to mediate several physiologic components of immunogenicity such as the acquisition of antigens in tissues, the migration to lymphoid organs, and the identification and activation of antigen-specific T cells.
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An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow.
Manfred B. Lutz,Nicole A. Kukutsch,A. L. J. Ogilvie,Susanne Rössner,Franz Koch,Nikolaus Romani,Gerold Schuler +6 more
TL;DR: This method allows by simple means the generation of high numbers of murine DC with very low B cell or granulocyte contaminations, which will be valuable to study DC biology notably at the molecular level.
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Chemokines and leukocyte traffic
TL;DR: Over the past ten years, numerous chemokines have been identified as attractants of different types of blood leukocytes to sites of infection and inflammation and are now known to also function as regulatory molecules in leukocyte maturation, traffic and homing of lymphocytes, and the development of lymphoid tissues.
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Mouse and human dendritic cell subtypes
Ken Shortman,Yong-Jun Liu +1 more
TL;DR: The dynamics of the DC network in response to microbial invasion is studied, because many DC subtypes arise from separate developmental pathways, and their development and function are modulated by exogenous factors.
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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.